results based on the results, medicinal plant extracts have marvelous effects on dandruff removal with fewer side effects, though it takes long time to treat the mentioned concern. conclusions the results show that applying the combination of medicinal plant extracts and natural ingredients with chemical compounds in pharmaceutical industry can optimize treatment. objectives the aim of this res...

OBJECTIVES The aim of this study was to identify changes in the gene expression profile of Candida albicans upon exposure to the hydroxypyridone anti-infective agent ciclopirox olamine in an effort to better understand its mechanism of action. METHODS C. albicans SC5314 was exposed to either medium alone or ciclopirox olamine at a concentration equivalent to the IC50 (0.24 mg/L) for 3 h. RNA ...

The hydroxypyridone ciclopirox olamine belongs to the antimycotic drugs used for the treatment of superficial mycoses. In contrast to the azoles and other antimycotic drugs, its specific mode of action is only poorly understood. To investigate the mode of action of ciclopirox olamine on fungal viability, pathogenicity, and drug resistance, we examined the expression patterns of 47 Candida albic...

Background: Dandruff especially with itching and inflammation is a common complaint among patients in the clinic and its treatment is much challenging. Chemical anti fungal substances used in antidandruff shampoos are common treatments. The aim of this study was to compare the clinical efficacy of two of these anti dandruff substances, climbazole and piroctone olamine in the treatment of dandru...

BACKGROUND It was recently confirmed that the antifungal agent ciclopirox olamine inhibits Wnt/beta catenin signaling in myeloma. Piroctone olamine (PO) has very similar chemical features to ciclopirox olamine. MATERIALS AND METHODS This study investigated the antitumor effect of PO in vitro and in vivo in a murine myeloma model. RESULTS PO demonstrated a major apoptotic activity in various...

This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (10(7)cells/ml in saline). The animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 m...

The external treatment of seborrheic dermatitis the scalp depends on withdrawal clinical symptoms and complaints patient made to doctor. At present Ukrainian dermatology has several dozen pharmacotherapeutic products in this direction, with dominating medicines ketoconazole, zinc pyrition, their combinations. They are characterized by short-term or weak effect, associated pathogenic microorgani...

Onychomycosis is a common fungal infection of nail plate caused by dermatophytes, non dermatophyte molds & yeasts. Tinea unguium on the other hand refers specifically to dermatophytes. represents 50% all disorders and 30% mycotic infections skin.1 It distributed worldwide with prevalence 3% 9%. generally considered as disease middle aged elderly affecting large significant number people. Th...