thrombotic thrombocytopenic purpura is the result of multiple thrombus disseminated in small arterioles throughout the body. principle damage is in the endothelium of small vessels and capillaries. from 1982 to 1999, 28 patients (16 female and 12 male) have been treated for ttp. the outcome was evaluated for risk factors and prognosis. these patients were 18 to 69 years old. all had neurologica...

A 29-year-old Englishman developed a lump on his head in September 1974. Three months later he presented with nocturia and tiredness. He looked ill, with a fluctuant swelling 3 cm by 3 cm over the right parietal bone; tenderness over the left ribs and lower thoracic spine; and some anterior angulation at D8. Haemoglobin was 6-0 g/dl, white blood count 4-1 x 109/1 (4100/mm3), erythrocyte sedimen...

Because the anion gap is useful in classifying acid-base disorders, quantitative information on this variable should be readily available. Three populations were studied and means and central 90% ranges were determined for the anion gap, calculated as sodium-(chloride + bicarbonate). In 1047 hospitalized patients the mean was 12 mEq/liter, 86 faster volunteers had a mean of 13 mEq/liter with a ...

Case report A 54-year-old man presented with one-week history of bilateral loin pain, reduced urine output and malaise. Complete blood picture showed hemoglobin of 7.6g/dL (normal: 11.5-17g/dL) Serum biochemistry showed hypercalcemia and markedly impaired renal function with creatinine measuring 1081 µmol/L (normal: 80-120). Skeletal survey showed multiple osteolytic lesions, and bone marrow as...

Guillain-Barré syndrome is the most common polyneuropathy causing major disability and respiratory failure. Respiratory complications are the main cause of death. Improved respiratory care and new treatment strategies such as plasmaphoresis and immunoglobulin have been shown to improve outcome. We studied the course and outcome of 37 patients with Guillain-Barré syndrome who were admitted to a ...

This paper describes the purification and partial char acterization of a putative pancreatic oncofetal antigen. Pancreatic oncofetal antigen is a glycoprotein with a molecular weight between 800,000 and 900,000, which migrates in the af to /3-region on electrophoresis. It is found in fetal pancreas and pancreatic cancer tissue, but it is not found in normal adult pancreas. Highly purified mater...