background: immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. this study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...

Background: Immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. This study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...

BACKGROUND Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies. Refractoriness can be diagnosed by laboratory tests and patients should receive compatible platelet transfusions. A fast, effective and low cost antibody-screening method which detects platelet human leukocyte/platelet ...

background leptospirosis is a systemic infectious disease caused by pathogenic bacteria belonging to the species of leptospira, it is considered to be the most common zoonosis in the world. this is a serious and sometimes fatal infection which is transmitted from animals to humans by entering the digestive tract or mucosal membrane. within the initial 10-12 day period, the patient may experienc...

A male, full-term baby with thrombocytopenia was born by a G3P2A1 mother who was not associated with autoimmune disease. Platelet antibody screening was positive by using lymphocytotoxicity test, platelet suspension immunofluorescence test and solid-phase red cell adherence test. The identified HLA antibody was of A2 specificity. It was confirmed by testing the mother's and the baby's sera agai...

Antibodies specifically reacting with platelets only in the presence of EDTA. by the platelet immunofluorescence test. were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination. These antibodies reacted optimally at 0-4’C. In 1 9 patients. IgG antibodies were detected; in 8 patients. 1gM or IgA antibodies were also found. In one pat...

Antibodies specifically reacting with platelets only in the presence of EDTA. by the platelet immunofluorescence test. were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination. These antibodies reacted optimally at 0-4’C. In 1 9 patients. IgG antibodies were detected; in 8 patients. 1gM or IgA antibodies were also found. In one pat...

The blood of twelve patients with parasitologically proved visceral leishmaniasis was examined for the presence of antibodies against blood cells. The direct antiglobulin test (Coombs' test) was positive in ten. IgG and complement were found on the red cells (alone or combined), but no IgA or IgM. In the serum of two, warm antibodies were found in the bromelin test. Pseudo-agglutination was det...