نتایج جستجو برای: plga nanoparticles

تعداد نتایج: 109205  

2010
Yuandong Ma Yi Zheng Kexin Liu Ge Tian Yan Tian Lei Xu Fei Yan Laiqiang Huang Lin Mei

Cancer is the leading cause of death worldwide. Nanomaterials and nanotechnologies could provide potential solutions. In this research, a novel biodegradable poly(lactide-co-glycolide)-d-a-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) random copolymer was synthesized from lactide, glycolide and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) by ring-opening polymerization u...

2009
M. K. Nkansah D. Thakral E. M. Shapiro

in MCF-7 human cancer cell line using magneic PLGA nanoparticles, dextran coated particles and empty PLGA nanoparticles.. Figure 1: Scanning electron microscopy (SEM) of nanoparticles with TEM inset showing distribution of magnetite cores. A) PLGA nanoparticles; B) PLGA microparticles; C) Cellulose nanoparticles. Particles are uniform in size, spherical and have high amounts of encapsulated mag...

2011
Lekha Nair K Sankar Jagadeeshan S Asha Nair GS Vinod Kumar

Nanoscaled devices have great potential for drug delivery applications due to their small size. In the present study, we report for the first time the preparation and evaluation of antitumor efficacy of 5-fluorouracil (5-FU)-entrapped poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles with dependence on the lactide/glycolide combination of PLGA. 5-FU-loaded PLGA nanoparticles with two dif...

2012
Chia Wen Liu Wen Jen Lin

BACKGROUND This study was performed to develop a functional poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG)-bearing amino-active end group for peptide conjugation. METHODS AND RESULTS PLGA was preactivated following by copolymerization with PEG diamine. The resulting amphiphilic PLGA-PEG copolymer bearing 97.0% of amino end groups had a critical micelle concentration of 3.0 × ...

2012
Yiran Ma Xinyi Zhao Jian Li Qi Shen

The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the various traditional and novel techniques of preparing daidzein-loaded PLGA nanoparticles, daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanop...

2011
Hongbo Chen Yi Zheng Ge Tian Yan Tian Xiaowei Zeng Gan Liu Kexin Liu Lei Li Zhen Li Lin Mei Laiqiang Huang

Three types of nanoparticle formulation from biodegradable PLGA-TPGS random copolymer were developed in this research for oral administration of anticancer drugs, which include DMAB-modified PLGA nanoparticles, unmodified PLGA-TPGS nanoparticles and DMAB-modified PLGA-TPGS nanoparticles. Firstly, the PLGA-TPGS random copolymer was synthesized and characterized. DMAB was used to increase retenti...

Journal: :iranian journal of pharmaceutical research 0
nima hamzian medical physics research center, mashhad university of medical sciences, mashhad, iran maryam hashemi nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran mahdi ghorbani medical physics research center, mashhad university of medical sciences, mashhad, iran mohammad hossein bahreyni toosi medical physics research center, mashhad university of medical sciences, mashhad, iran mohammad ramezani pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

the aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates spion and gemcitabine in plga±peg to form multifunctional drug delivery system. for this aim, super paramagnetic iron oxide nanoparticles (spions) were synthesized and encapsulated simultaneously with gemcitabine (gem) in plga±peg copolymers via w/o/w double emulsification method. optimum size and enca...

Journal: :International Journal of Nanomedicine 2006
Soodabeh Davaran Mohammad R Rashidi Behzad Pourabbas Mahin Dadashzadeh Naser Moti Haghshenas

The preparation, properties, and application in adriamycin delivery ofbiocompatible and biodegradable poly(lactide-co-glycolide)-polyethylene glycol (PLGA-PEG) nanoparticles are discussed. PLGA-PEG copolymers were synthesized by ring opening polymerization of the dl-lactide and glycolide in the presence of PEG1000. 1H-NMR and FT-IR spectrum were consistent with the structure of PLGA-PEG copolym...

Journal: :Chemical communications 2012
Aneta J Mieszawska Anita Gianella David P Cormode Yiming Zhao Andries Meijerink Robert Langer Omid C Farokhzad Zahi A Fayad Willem J M Mulder

Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate p...

2014
LIANG XU HUA LI YUBIN WANG FANG DONG HUANGBING WANG SHUTONG ZHANG

Effective chemotherapy remains an important issue in the treatment of drug resistant cancer. The aim of the present study was to establish novel polymeric nanoparticles composed of the antitumor drug, doxorubicin (DOX), and an inhibitor of the drug efflux pump-associated protein, P-glycoprotein (P-gp), in order to overcome drug resistance in tumor cells. Poly(D,L-lactide-co-glycolide) (PLGA), D...

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