The straightforward enantioselective construction of the hydroquinoline ring system from 1,5-polycarbonyl derivatives, using (R)-phenyglycinol as a chiral latent form of ammonia, is reported. The process mimics the key steps believed to occur in nature in the biosynthesis of amphibian decahydroquinoline alkaloids. Diastereodivergent routes to enantiopure cis-2,5-disubstituted decahydroquinoline...

In this paper we study the structure and thermochemical properties of some new polycarbonyl compounds, with particular attention devoted to the study of (CO)n complexes, which are expected to be present in magnegases . The latter are anomalous gases produced by Hadronic Reactors of molecular type [2] (Patented and International Patents Pending) which expose atoms to the extremely intense electr...

ome of the most useful reactions of carbonyl compounds involve carbonhydrogen bonds adjacent to the carbonyl group. Such reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of the hydrogen by some other atom or group, as in the I I I I sequence H-C-C=O -+ X-C-C=O. The important examples we I I will consider in this chapter are ...

Condensation of aromatic aldehydes with benzoyl acetone under specified conditions yieldedtwo series of polycarbonyl compounds in which the keto group is attached to olefinic linkage.Spectral and analytical data revealed the formation of an unsaturated triketone from pyridine-3-carbaldehyde and unsaturated diketone from furfural, salicylaldehyde and 2-hydroxynaphthaldehyde. Analytical, IR, 1H N...

condensation of aromatic aldehydes with benzoyl acetone under specified conditions yieldedtwo series of polycarbonyl compounds in which the keto group is attached to olefinic linkage.spectral and analytical data revealed the formation of an unsaturated triketone from pyridine-3-carbaldehyde and unsaturated diketone from furfural, salicylaldehyde and 2-hydroxynaphthaldehyde. analytical, ir, 1h n...

An efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as s...

series. This compound and many related com pounds are active against Sarcoma 180, particu larly when administered orally in the diet. Glyoxal bis(thiosemicarbazone) has a low toxicity for mice. Some of the more active compounds first synthe sized and tested gave an undesirable side effect of weight loss. However, further synthesis and test ing led to compounds of higher activity, low tox icity,...