Cancer is one of the major life threatening diseases worldwide. Many studies are in progress to inhibit the rate of distribution of the proteins involved in cancer. The Aloe Vera compounds were checked against the molecular targets of cancer by molecular docking studies. The compounds n-Hexadecanoic acid and tertadecanoic acid were found to interact more towards the target protein showing highe...

As the industrial landscape is altered by emerging markets like China and India and the bankruptcy of Detroit automakers and their parts suppliers, motor vehicle firms are reconfiguring their supply chains in order to be cost-competitive on a global basis. Backup capacity and cross-docking are being incorporated into just-in-time delivery systems in an attempt to keep car prices affordable for ...

Proper distribution of mitochondria within axons and at synapses is critical for neuronal function. While one-third of axonal mitochondria are mobile, a large proportion remains in a stationary phase. However, the mechanisms controlling mitochondrial docking within axons remain elusive. Here, we report a role for axon-targeted syntaphilin (SNPH) in mitochondrial docking through its interaction ...

Side-chain or even backbone adjustments upon docking of different ligands to the same protein structure, a phenomenon known as induced fit, are frequently observed. Sometimes point mutations within the active site influence the ligand binding of proteins. Furthermore, for homology derived protein structures there are often ambiguities in side-chain placement and uncertainties in loop modeling w...

   In cross docking strategy, arrived products are immediately classified, sorted and organized with respect to their destination. Among all the problems related to this strategy, the vehicle routing problem (VRP) is very important and of special attention in modern technology. This paper addresses the particular type of VRP, called VRPCDTW, considering a time limitation for each customer/retai...

Pex3p and Pex19p are key players in the post-translational import of peroxisomal membrane proteins. New data suggest that these peroxins act in tandem, Pex19p as a cytosolic chaperone and import receptor for peroxisomal membrane proteins, and Pex3p as docking factor at the peroxisomal membrane.

this is the first study to attempt to explain income inequality using unemployment and inflation and international cross-sectional data. using a sure system, inflation is found to have an increasing impact on the shares of the lower 80% of the income distribution, while reducing the share of the highest 20%. unemployment has a negative effect on the share of the first 40%, while increases the s...

We consider in this article the Two-Machine Cross-Docking Flow Shop problem, which is a special case of scheduling with typed tasks, where we have two types of tasks and one machine per type. Precedence constraints exist between tasks, but only from a task of the first type to a task of the second type. The precedence relation is thus a directed bipartite graph. Minimizing the makespan is stron...

Cross docking is a warehouse management concept in which items delivered to a warehouse by inbound trucks are immediately sorted out, reorganized based on customer demands and loaded into outbound trucks for delivery to customers, without requiring excessive inventory at the warehouse. Compared to traditional warehousing, the storage as well as the length of the stay of a product in the warehou...

In genetic algorithm (GA), there are two main methods of determining trial candidates: crossover and mutation. While crossover directs search between fit candidates, mutation plays a role on jumping out local optimal. In molecular docking calculations, it is desirable to chart as much unexplored search space as possible. Therefore it is desirable that mutation results in a uniform distribution ...