Alternative pre-mRNA splicing expands the complexity of the transcriptome and controls isoform-specific gene expression. Whether alternative splicing contributes to metabolic regulation is largely unknown. Here we investigated the contribution of alternative splicing to the development of diet-induced obesity. We found that obesity-induced changes in adipocyte gene expression include alternativ...

Use of BMI as a surrogate for body fat percentage is debatable and universal BMI cut-off points do not scern appropriate; lower cut-off points than currently recommended by WHO should be used in some populations, especially in Asia. The adult WHO BMI database indicates that, on average, wornen are rnore obese than men, while mcn are more Iikely to be pre-obese than women. Urban rates of overwei...

Background: Pre-diabetes is a state where glucose level higher than normal, but not satisfy the criteria for diabetes. This condition is very critical, so that if subject don’t do lifestyle modification and pharmacology therapy, they could fall to diabetes. This research objective is to describe the prevalence and predictors of pre-diabetes in Indonesia. Methods: A cross-sectional study was con...

Introduction: One of the risk factors seen most frequently in obstetric practice is maternal obesity. Women who were overweight or obese made up more than half all female fatalities due to direct indirect causes. Obesity increases chance that mother will experience problems during pregnancy, labour, and delivery, making fetal assessment technically difficult. Methods: This study uses quantitati...

BACKGROUND Prevention of pre-hypertension is an important goal for primary care patients. Obesity is a risk factor for hypertension, but has not been addressed for pre-hypertension in primary care populations. The objective of this study was to assess the degree to which obesity independently is associated with risk for pre-hypertension in family medicine patients. METHODS This study was a re...

Severe obesity affects metabolism with potential to influence the lactate and glycemic response to different exercise intensities in untrained and trained rats. Here we evaluated metabolic thresholds and maximal aerobic capacity in rats with severe obesity and lean counterparts at pre- and post-training. Zucker rats (obese: n = 10, lean: n = 10) were submitted to constant treadmill bouts, to de...

Sida rhomboidea. Roxb leaf extract (SRLE) is being used by the populace of North-East India to alleviate symptoms of diabetes and obesity. We have previously reported its hypolipidemic and anti-diabetic properties. In this study, we report the effect of SRLE on (i) in vivo modulation of genes controlling high fat diet (HFD) induced obesity and (ii) in vitro 3T3L1 pre-adipocyte differentiation a...

The vulnerability to develop certain pathophysiological conditions may be linked the morphogenetic traits of individuals. Hence, this study ascertained relationship between some and physiological coefficients related incidence obesity, hypertension, diabetes mellitus. Morphogenetic (height, weight, ABO blood group, Hitchhiker thumb, tongue rolling, hand clasping) coefficients; body mass index, ...

BACKGROUND & OBJECTIVE Overweight and obesity are important determinants of health leading to adverse metabolic changes and increase the risk of non communicable diseases. Following the increase in adult obesity, the proportion of overweight and obese children and adolescents has also been increasing. Hence, the present study was undertaken to study the magnitude of overweight/obesity and its c...