OBJECTIVE To investigate the effects of pregestational, as opposed to gestational, diabetes on infant malformations. METHODS All women delivering infants at Parkland Hospital between January 1, 1991, and December 31, 2000, were ascertained. Screening for gestational diabetes was methodically employed throughout the study period using National Diabetes Data Group criteria for diagnosis of preg...

BACKGROUND Pregestational diabetes is a major risk factor of congenital heart defects (CHDs). Glutathione is depleted and reactive oxygen species (ROS) production is elevated in diabetes. In the present study, we aimed to examine whether treatment with N-acetylcysteine (NAC), which increases glutathione synthesis and inhibits ROS production, prevents CHDs induced by pregestational diabetes. M...

BACKGROUND Maternal diabetes mellitus is associated with an increased risk of offspring congenital heart defects (CHD); however, the causal mechanism is poorly understood. We further investigated this association in a Danish nationwide cohort. METHODS AND RESULTS In a national cohort study, we identified 2 025 727 persons born from 1978 to 2011; among them were 7296 (0.36%) persons exposed to...

OBJECTIVE To describe the characteristics of pregnant women with and without pregestational diabetes and to estimate the prevalence of pregestational diabetes in pregnant women recorded in a UK primary care database. METHODS The data source for this study is The Health Improvement Network (THIN) primary care database. Pregnant women with and without diabetes aged 16 years and over were identi...

BACKGROUND Women with pregnancy complicated by pregestational diabetes experience increased rates of adverse pregnancy outcomes. Prepregnancy care is the targeted support and additional care offered to those women who are planning pregnancy and is associated with improved outcomes. However, there is significant heterogeneity in the outcomes measured and reported in studies evaluating the effect...

OBJECTIVE This study examined the effect of maternal pregestational type 1 diabetes on offspring primary school performance. RESEARCH DESIGN AND METHODS We performed a prospective combined clinical and register-based cohort study comparing primary school performance in offspring (n = 707) of women with pregestational type 1 diabetes with matched control offspring (n = 60,341). We also examine...

Data from birth certificates in the United States indicate that maternal diabetes complicates 2%-3% of all pregnancies, but these data may underestimate the true prevalence of maternal diabetes in pregnancy. Two major forms of maternal diabetes may occur during pregnancy: preexisting or "pregestational" diabetes, and gestational-onset or gestational diabetes mellitus (GDM). Only the former is k...

OBJECTIVE We investigated the association between functional health literacy and markers of pregnancy preparedness in women with pregestational diabetes. RESEARCH DESIGN AND METHODS English- and Spanish-speaking pregnant women with pregestational diabetes were recruited. Women completed the Test of Functional Health Literacy in Adults (TOFHLA) short form and a questionnaire. A TOFHLA score of...

- to compare colonization of group b streptococcus (gbs) in diabetic and non-diabetic pregnant women. in this prospective study 50 pregnant women with diabetes mellitus (both pregestational and gestational) and 43 pregnant women without diabetes between 33 and 37 weeks' gestation were evaluated. three samples for group b streptococcal culture detection were obtained from each subject in the fol...

The following highlights spotlight several standout abstracts presented at the 58th European Association for Study of Diabetes (EASD) Annual Meeting, covering topics such as effects extended overnight fasting, incidence congenital heart defects in offspring females diagnosed with pregestational diabetes, and telehealth metabolic control Type 1 diabetes.