background: misoprostol, a prostaglandin e1 analogue compared to prostaglandin e2, has the advantage of being inexpensive and stable at room temperature, with its proven efficacy and safety. however studies on the effect of ph on the efficacy of misoprostol have yielded conflicting results. thus its use in the induction of labour in patients with premature rupture of membrane requires further i...

Objective: To study the determinants and outcome of prelabour rupture of membrane at term pregnancy in Patan Hospital. Method: A prospective, hospital based case control study done in maternity ward of Patan Hospital over the period of three months (Poush 2059-Phalgun 2059). A total no of 100 pregnant women with prelabor rupture of membrane and 100 pregnant women without prelabor rupture of mem...

INTRODUCTION If left untreated, severe combined immunodeficiency can lead to an acute susceptibility to infection. The intrauterine environment is sterile until the amniotic membranes rupture. The vaginal flora then ascends into the genital tract, thus increasing the risk of chorioamnionitis. An extremely premature and prolonged membrane rupture is associated with a dismal prognosis for an immu...

Background: Prelabour rupture of membrane is defined as a before onset labour and in the absence uterine contraction. When it occurs 37weeks preterm PROM. One most common complication delivery approximately 7-10% account for 1-2% foetal death. Most commonly associated with subclinical UTI. Methods: A prospective study was conducted from (June 2021-June 2022) at tertiary health care hospital. Al...

The problem Unfortunately there are too many examples in obstetrics of very important conditions for which there is no consensus of professional opinion about definition, diagnosis, risks, and above all, management. Preterm prelabour rupture of the membranes (PPROM) is such a case. The best, most widely used, and simplest definition of PPROM is membrane rupture occurring before the onset of reg...

Objectives: To compare the fetal and maternal outcomes in interventional (induction of labor) verses expectant management prelabour rupture membranes at term.Materials Methods: This Randomized control trial was conducted from December 2014 to June 2015 obstetrics gynecology department civil hospital Karachi.. A total 284 patients were recruited via non probability consecutive sampling technique...