A new method has been developed to define the directional parameter and characterize the structural anisotropy of a highly porous structure with extensive pore interconnectivity and surface area, such as scaffolds in tissue engineering. This new method called intercept segment deviation (ISD) was validated through the comparison of structural anisotropy from ISD measurements with mechanical ani...

Bones constructed by tissue engineering are being considered as valuable materials to be used for regeneration of large defects in natural bone. In an attempt to prepare a new bone construct, in this study, proliferation and bone differentiation of marrow-derived mesenchymal stem cells (MSCs) on our recently developed composite scaffolds of nano-, micro-hydroxyapatite/ poly(l-lactic acid) were ...

Objective(s): Bone tissue engineering is aimed at the fabrication of bone graft to ameliorate bone defects without using autografts or allografts. Materials and Methods: In the present study, the coprecipitation method was used to prepare hydroxyapatite (HA) nanoparticles containing nandrolone. To do so, 12.5, 25, and 50 mg of nandrolone were loaded into poly(lactic acid) (PLA)/nano-HA, a...

At the conclusion of the famous article of 1953 announcing the molecular structure of DNA, Watson and Crick observed “that the specific pairing we have postulated immediately suggests a possible copying mechanism for genetic material.” Six months later, Pope Pius XII addressed the First International Conference of Medical Genetics on ethical issues. The Pope said that since the aim of genetics ...

The purpose of this paper is to problematize the idea of the ethnographic field that is usually taken for granted in Information Systems (IS) field research. The field is the touchstone of reality which the ethnographer encounters yet it is often thought of something fixed and merely ‘out there’ where the ethnographer goes to conduct the research. However, recent advances in anthropological sch...

heart failure is one of the leading causes of death worldwide. end stage disease often requires heart transplantation, which is hampered by donor organ shortage. tissue engineering represents a promising alternative approach for cardiac repair. for the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. in this revi...

objective: the bioscaffold can be used in tissue engineering and regenerative medicine. the scaffolds used in tissue engineering must have high porosity to facilitate accelerated angiogenesis for feeding cells and repelling cell waste outside the scaffold. in this experimental study, we attempted to produce lung three-dimensional scaffold and assay its effect on cell penetration and migration. ...

aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (pcl), poly (vinyl alcohol) (pva) and hydroxyapatite nanoparticles (nha). the morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...