background: because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (tnbc) tumors have remained as an important area of investigations for clinicians and researchers. the aim of this study was to determine the clinical, pathological, histological, prognostic features, and outcome associated with this type of breast cance...

Background:Treatment of recurrent breast cancer, like treatment early-stage is based on consideration tumor biology and clinical history. Thus, characterization hormonal HER2 status critical for all patients, a detailed assessment past treatment, including timing therapies as well patient symptoms functional assessment, essential. Determination hormone receptor should be repeated in cases first...

Introduction: The effective method of treatment of Polycystic Overy Syndrome (PCOS) is lifestyle modification. The aim of this study was to evaluate the effect of 12 weeks aerobic exercise on DHEAso4, 17OH-Progestron Concentrations, number of follicles and menstrual condition of women with PCOS. Methods: In this clinical trial, 40 PCOS patients lean (BMI<20) and obese (BMI>25) randomly divided ...

results in patients with high breast densities, malignant cases (61.2%) were significantly more in comparison to patients with low breast densities (37.3%) (p= 0.007, or=2.66 95% ci=1.29-5.49). after adjusting for age, density was associated with malignancy in age groups <46 years (p=0.007), and 46-60 years (p=0.024) but not in age group >60yrs (p=0.559). adjusting for menopausal status, densit...

recent studies have shown that glucocorticoids may have modulatory effect on anxiety reactions. this effect may occur with opioid system interference. according to that, the purpose of this research is to assess the effect of dexamethasone as glucocorticoid agonist and its interaction with opioidergic system on the anxiety modulatory effect in plus maze model in mice. male white mice with mediu...

discussions in comparison to the control of wy14643, sandoz58-035, c9 and t11-cla, epa increased the pparα mrna levels (p = 0.024, p = 0.041, p = 0.043, and p = 0.004, respectively), even though, la had no significant effect on the pparα mrna expression (p = 0.489). materials and methods this experimental study investigated the effects of c9, t11-conjugated linoleic acid (c9, t11-cla). alpha li...

results the tlr3 protein in the ach group tended toward reduction although the p value of the comparison between the ach group and hd group was not statistically significant. the tlr3 levels in the hcc, ac, and cir groups were higher than those in the hd and ach groups. tlr3 was not interrelated with all costimulation proteins in the dcs and t cells in all five groups. no group presented any in...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

conclusions p. gingivalis and p. intermedia could play a role in implant failure by changing the expression profiles of genes related to bone formation and resorption. results viability was reduced to 56.8% (p. gingivalis) and 52.75% (p. intermedia) at 1000 multiplicity. amongst 48 genes examined, expressions of bmper, smad1, il8 and nfrkb were found to be highly upregulated by both bacterial c...