PURPOSE The possibility of providing cultured corneal endothelial cells (CECs) for clinical transplantation has gained much attention. However, the worldwide need for human (h) donor corneas far exceeds supply. The pig (p) might provide an alternative source. The aim of this study was to compare the proliferative capacity of CECs from wild-type (WT) pigs, genetically-engineered (GE) pigs, and h...

Objective: This study focused on the antibacterial and anti-proliferative activity of extracts from Carica papaya Cocos nucifera roots. Methodology: The minimum inhibitory concentration bactericidal Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, Staphylococcus aureus were deduced by microdilution method. anti-biofilm was determined all four strains anti-quorum sensing inhibitio...

BACKGROUND Lung cancers are leading causes of cancer death, and Rumex japonicus has been traditionally used in folk medicine as anti-microorganic, anti-inflammatory and anti-tumor agents. This study was designed to investigate the anti-proliferative activity of physcion 8-O-β-glucopyranoside (PG) isolated from Rumex japonicus Houtt. on A549 cell lines. METHODS In our present study, PG was iso...

BACKGROUND One of the major morphologic characteristics of hepatitis B is a hepatocellular regeneration which is induced by massive hepatocyte necrosis and associated with proliferative activity of hepatocytes. The purpose of this study is to document the proliferative activity of hepatocytes in various types of hepatitis B by immunohistochemical staining for proliferative cell nuclear antigen-...

objective(s):marine organisms are known as a potential source of natural products, which contain bioactive substances with therapeutic properties. sea cucumbers are prominent among marine organisms because of their dietary and therapeutic applications. in addition, they have capacity of synthesizing saponins molecules and other metabolites with therapeutic properties such as antitumor, antimicr...

The enlargement of the thyroid is, in general, benign in origin and due to nodular goitre. Follicular cellular proliferation of thyroid nodules has been increasingly observed recently. With fine needle aspiration biopsy (FNAB) this is classified as a follicular tumour. These lesions present various patterns of vascularisation in ultrasound examination. The aim of the study was to establish the ...

BACKGROUND Forkhead box P3 (Foxp3) functions as a master regulator in the development and function of T-regulatory (Treg) cells. Recent studies have shown that autoimmune diseases including systemic lupus erythematosus (SLE) are associated with an imbalance with the Treg cells and T helper (Th) subtypes. OBJECTIVES To evaluate immunohistochemical expression of Foxp3 positive Treg cells in lup...

Background and objectives: The aerial parts of Artemisia marschalliana Sprengel as an indigenous species of genus Artemisia in the East Azerbaijan province of Iran, was subjected to phytochemical analysis, as well asanti-proliferative, free-radical-scavenging and anti-malarialactivities. Methods: The chemical composition of the essential oil o...

Background: Chemotherapy or irradiation is associated with impaired fertility. The aim of this study was to investigate the possible protective role of testosterone enanthate (TE) on the proliferative activity, plasma testosterone level and morphometry of epithelial cells of seminal vesicles in busulfan-induced spermiotoxicity. Materials and Methods: Sprague- Dawley rats were divided into 4 gro...