Small non-coding ribonucleic acids (RNAs), known as microRNAs (miRNAs), are now becoming recognized as significant agents that can affect the onset and progression of numerous disorders throughout the body. In particular, miRNAs also may determine stem cell renewal and differentiation. Intimately tied to the ability of miRNAs to govern stem cell proliferation are the proliferative pathways of s...

Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma (MM), is one of the most common premalignant conditions in the general population. The cause of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of persons with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of ...

Early detection of oral squamous cell carcinoma (OSCC) and potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half patients with cancer had advanced disease at the time diagnosis, indicating a lack early risk assessment biomarkers. The development new protein biomarkers will help in diagnosis treatment.The argyrophilic nucle...

background: peroxisome proliferative-activated receptors (ppars) are nuclear receptors that involved in cellular lipid metabolism and differentiation. the subtype ? of the ppar family (ppar?) plays important roles in physiologic functions of ovaries. objective: to determine correlation between ppar? protein level in granulosa cells and pregnancy rate in women undergoing in-vitro fertilization (...

Many congenital and acquired bone marrow disorders have been described in dogs. Major categories include infectious diseases, immune-mediated bone marrow destruction, toxic marrow injury, congenital and acquired myelodysplastic syndromes, acute and chronic myeloproliferative and lymphoproliferative disorders, primary polycythemia, primary and secondary myelofibrosis, malignant histiocytosis, he...

In this mini-review we present recent data about origin of GABA-ergic (gama-aminobutyric acid) neurons in the mammalian forebrain, including the diencephalon and telencephalon. The interest in GABA-ergic neurons, which in cerebral cortex mostly correspond to local circuit neurons (interneurons), has increased in the past decade. Many studies have shown that in lower mammals all hippocampal and ...