Objective: Investigations were carried out to isolate bacteria from saline-alkali soils and determined optimized alkaline protease activity and stability produced by a wild strain of bacillus sp. in submerged fermentation (SMF). Methods: Optimum temperature for enzyme activity in the crude extract was 40 ◦C at a pH between 8.0 and 9.0. The studies on pH stability showed that the enzyme...

background: subtilisin -like proteases are the group of proteases including keratinases found in dermatophytes which de­graded keratin. determination of the proteases activity of trichophyton vanbreuseghemii isolates which were obtained from soil and clinical and soil isolates of microsporum gypseum in iran and characterization of their genome were aim of present study. methods: ezymatic activi...

background and objectives: thermophilic bacteria are less studied but important group of microorganisms due to their ability to produce industrial enzymes. materials and methods: in this study, thermophilic bacteria were isolated from hot spring of tarabalo, india. a bacterium that could tolerate high temperatures was characterized by morphology, biochemistry and sequencing of its 16s rrna gene...

the present study was conducted to evaluate the effect of dietary inclusion of silver nanoparticle on general performance and digestive proteases in zebra fish. four experimental diets were designed with a concentration of 5, 20 and 40 parts per billion (ppb) nanoparticles in the diet (named s5, s20, and s40, respectively) and control group without any nanoparticles (s0). there was no significa...

furin is a ca 2+ -dependent serine protease which cleaves proprotein substrates at the arg-xaa-(lys/arg)-arg    site to generate biologically active proteins. furin’s critical role in many cellular events associated with health disorders such as hiv, sars, anthrax, and influenza as well as cancer has made inhibitors of this enzyme as therapeutic targets. to this date, the most potent inhibitor ...

conclusions the incidence of mbls producing p. aeruginosa in patients with cf was not low. the findings indicate that the identification of drug-resistance patterns in p. aeruginosa and the detection of mbl-producing isolates are important in the prevention and control of infections. background respiratory infections caused by pseudomonas aeruginosa play an important role in the pathogenesis of...

random peptide libraries (rpl) displayed on the surface of filamentous bacteriophages have been extensively used as a tool to map epitopes or to identify antigenic mimics (mimotpoes) of disease-specific monoclonal antibodies or polyclonal sera. these rpl are engineered by the insertion of degenerate oligonucleotides, encoding a specific number of random amino acids, in frame with a bacteriophag...

Background and Aims: Human lymphotropic virus type-1 (HTLV-1) causes various diseases such as adult T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM / TSP) in humans. The main goal of this study is to compare Iranian protease subtypes structure of this virus (HTLV-1) to samples collected from other part of world in order to understand their diff...

SARS-CoV-2, a new type of Coronavirus, has affected more millions people worldwide. From the spread this infection, many studies related to virus and drug designing for treatment have been started. Most target SARS-CoV-2 main protease, spike protein SASR-CoV-2, some are targeting human furin protease. In current work, we chose clinically used molecules remdesivir, favipiravir, lopinavir, hydrox...