DNA polymerase III holoenzyme is responsible for chromosomal replication in bacteria. The components and functions of Escherichia coli DNA polymerase III holoenzyme have been studied extensively. Here, we report the reconstitution of replicase activity by essential components of DNA polymerase holoenzyme from the pathogen Pseudomonas aeruginosa. We have expressed and purified the processivity f...

abstract background: research shows that the age at menarche, as an essential element in the reproductive health of women, had been decreasing in the 19th and 20th centuries, and shows a huge variation across different countries. there are numerous studies performed in iran reporting a range of age at menarche. thus, this meta-analysis aimed to determine the overall mean age at menarche of the ...

Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD). We have previously shown that the KP is over activated in AD brain and that QA accumulates in amyloid plaques and within dystrophic neurons. We hypothesized that QA in pathophysiolo...

Tauopathy, a major pathology in Alzheimer's disease, is also found in ~50% of frontotemporal dementias (FTDs). Tau transcript, a product of a single gene, undergoes alternative splicing to yield 6 protein species, each with either 3 or 4 microtubule binding repeat domains (tau 3R or 4R, associated with dynamic and stable microtubules, respectively). While the healthy human brain shows a 1/1 rat...

In this paper the periodic solutions of fourth order delay differential equation of the form $ddddot{x}(t)+adddot{x}(t)+f(ddot{x}(t-tau(t)))+g(dot{x}(t-tau(t)))+h({x}(t-tau(t)))=p(t)$  is investigated. Some new positive periodic criteria are given.  

The goal of this study is to investigate the value of tau phosphorylated at threonine 181 (P-tau181P) in the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker panel for differential dementia diagnosis in autopsy confirmed AD and non-AD patients. The study population consisted of 140 autopsy confirmed AD and 77 autopsy confirmed non-AD dementia patients. CSF concentrations of amyloid-...

Axion-Like Particles (ALPs) are pseudo Nambu-Goldstone bosons associated with spontaneously broken global $U(1)$ symmetries. Such particles can have lepton-flavor-violating (LFV) couplings to the SM charged leptons. LFV ALPs provide possibility address some of long-lasting problems. We investigate sensitivity a future muon collider suggested by Muon Accelerator Program (MAP) production in ALP m...

chamomile is a medicinal plant with high economic value. in this research, 20 chamomile ecotypes collected from different regions of iran were evaluated for genetic and chemical diversity. dna was extracted by ctab and polymerase chain reaction was performed using 13 rapd markers. essential oils extraction was performed by water distillation using clevenger system. components of the essential o...