BACKGROUND Total tau (T-tau) and beta-amyloid((1-42)) (Abeta(1-42)) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia. Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult. METHODS The analytical performance of the INNOTEST PHOSPHO-TAU(181P) assay was validated in terms of sel...

Within the resonance chiral theory (RχT), we have studied the process of a tau lepton decaying into a vector resonance plus a pseudo-Goldstone meson and a tau neutrino. Two kinds of processes are discussed: (a) τ− → (ρπ, ωπ−, φπ,KK)ντ , belonging to ∆S = 0 processes and (b) ∆S = 1 processes, such as τ− → (ρK, ωK−, φK−,K ∗0 π−)ντ . To fit the τ − → ωπ−ντ spectral function and the decay distribut...

this article presents a unified approach to the abstract notions of partial convolution and involution in $l^p$-function spaces over semi-direct product of locally compact groups. let $h$ and $k$ be locally compact groups and $tau:hto aut(k)$ be a continuous homomorphism.  let $g_tau=hltimes_tau k$ be the semi-direct product of $h$ and $k$ with respect to $tau$. we define left and right $tau$-c...

Consider a bounded strongly pseudo-convex domain Ω with smooth boundary in Cn. Let T be the Toeplitz algebra on Bergman space La2(Ω). That is, is C⁎-algebra generated by operators {Tf:f∈L∞(Ω)}. Extending work [27], [28] special case of unit ball, we show that any such Ω, and {Tf:f∈VObdd}+K are essential commutants each other, where K collection compact On general considered this paper, proofs r...

The crosstalk between microtubules and actin is essential for cellular functions. However, mechanisms underlying the microtubule-actin organization by cross-linkers remain largely unexplored. Here, we report that tau, a neuronal microtubule-associated protein, binds to microtubules and actin simultaneously, promoting in vitro co-organization and coupled growth of both networks. By developing an...

Leucine-rich repeat kinase 2 (LRRK2), a large protein kinase containing multi-functional domains, has been identified as the causal molecule for autosomal-dominant Parkinson's disease (PD). In the present study, we demonstrated for the first time that (i) LRRK2 interacts with tau in a tubulin-dependent manner; (ii) LRRK2 directly phosphorylates tubulin-associated tau, but not free tau; (iii) LR...

Elevated tau expression has been proposed as a possible basis for impaired axonal transport in Alzheimer's disease. To address this hypothesis, we analyzed the movement of pulse radiolabeled proteins in vivo along retinal ganglion cell (RGC) axons of mice that lack tau or overexpress human tau isoforms. Here, we show that the global axonal transport rates of slow and fast transport cargoes in a...