نتایج جستجو برای: psoriasiform

تعداد نتایج: 493  

Journal: :Journal of Crohn's & colitis 2014
Anita Afzali Chelle L Wheat Jie Kate Hu John E Olerud Scott D Lee

BACKGROUND & AIMS Anti-tumor necrosis factors (anti-TNF) including infliximab, adalimumab and certolizumab pegol are used to treat Crohn's disease (CD) and ulcerative colitis (UC). Paradoxically, while also indicated for the treatment of psoriasis, anti-TNF therapy has been associated with development of psoriasiform lesions in IBD patients and can compel discontinuation of therapy. We aim to i...

2016
Tiffany Y Loh Philip R Cohen

BACKGROUND Tumor necrosis factor-α (TNF-α) inhibitors, such as infliximab, adalimumab, and certolizumab pegol are effective agents in the treatment of inflammatory bowel disease. Some individuals undergoing anti-TNF-α therapy for Crohn's disease or ulcerative colitis develop psoriasiform lesions. This is a paradoxical finding, as classical psoriasis is known to respond to these agents. PURPOS...

2016
Vusal Veliyev İbrahim Özmen Salim Yaşar Erol Gürsoy Mustafa Köklü Murat Çelik

Psoriasiform drug eruptions are very rare and generally characterized as erythematous, thick, dry, squamous, and demarcated plaques, resembling those of idiopathic psoriasis (1). Drugs may result in the exacerbation of pre-existing psoriasis or initiation of de novo psoriatic lesions (2). Apixaban, a reversible direct inhibitor factor Xa, is a novel anticoagulant, and its side effects mainly in...

2016
Sihyeok Jang In Su Kim Sang Woong Youn

Graft-versus-host disease (GVHD) is a common complication of bone marrow transplantation (BMT) that can be classified as acute or chronic. Chronic GVHD, which usually occurs more than 3 months after BMT, includes typical lichenoid or sclerodermatous lesions. Psoriasiform eruption is a rare clinical manifestation of chronic GVHD, and there have been no reports of psoriasiform chronic GVHD associ...

Journal: :Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2010
Jean-François Rahier Sébastien Buche Laurent Peyrin-Biroulet Yoram Bouhnik Bernard Duclos Edouard Louis Pavol Papay Matthieu Allez Jacques Cosnes Antoine Cortot David Laharie Jean-Marie Reimund Marc Lémann Emmanuel Delaporte Jean-Frédéric Colombel

BACKGROUND & AIMS Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-α therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNF-α agents. METHODS We studied 85 patients (69 with Crohn's disease, 15...

Journal: :Gut 2014
Cornelia Tillack Laura Maximiliane Ehmann Matthias Friedrich Rüdiger P Laubender Pavol Papay Harald Vogelsang Johannes Stallhofer Florian Beigel Andrea Bedynek Martin Wetzke Harald Maier Maria Koburger Johanna Wagner Jürgen Glas Julia Diegelmann Sarah Koglin Yvonne Dombrowski Jürgen Schauber Andreas Wollenberg Stephan Brand

BACKGROUND We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions in patients with inflammatory bowel diseases (IBD). DESIGN Patients with IBD were prospectively screened for anti-TNF-induced psoriasiform skin lesions. Patients were genotyped for IL23R and IL12B variants. Skin ...

Journal: :Indian journal of dermatology, venereology and leprology 2009
Shilpa Mehta Archana Singal Navjeevan Singh Sambit Nath Bhattacharya

BACKGROUND Psoriasis has different clinical variants, which mimic diverse dermatological conditions and may require a histopathological confirmation of the diagnosis. Studies to establish a clinicohistopathological concordance (and its determinants), in psoriasis and psoriasiform dermatitis are lacking. AIMS The present study was designed (a) to correlate the clinicohistopathological features...

2014
Carla Andréa Avelar Pires Brena Andrade de Sousa Carla do Socorro Silva do Nascimento Ana Thais Machado Moutinho Mario Fernando Ribeiro de Miranda Francisca Regina Oliveira Carneiro

Psoriasiform Keratosis is a rare clinic entity. The etiopathogenesis remains unknown and the disease is characterized by a solitary, scaly or keratotic papule, or plaque mainly located on the extremities. Histopathological features closely resemble those of psoriasis. We report the case of a 70-year-old woman presenting a solitary and asymptomatic keratotic plaque, located on the back of the le...

Journal: :Experimental dermatology 2007
Stephen Hsu Douglas Dickinson James Borke Douglas S Walsh Joseph Wood Haiyan Qin Julia Winger Henna Pearl George Schuster Wendy B Bollag

Psoriasiform lesions are characterized by hyperproliferation and aberrant differentiation of epidermal keratinocytes, accompanied by inflammation, leading to a disrupted skin barrier with an abnormal stratum corneum. The expression and proteolytic processing of caspase 14, a member of the caspase family which is associated with epithelial cell differentiation, planned cell death, and barrier fo...

Journal: :Journal of immunology 2008
Honglin Wang Daniel Kess Anna-Karin B Lindqvist Thorsten Peters Anca Sindrilaru Meinhard Wlaschek Robert Blakytny Rikard Holmdahl Karin Scharffetter-Kochanek

Psoriasis is a complex genetic disease of unresolved pathogenesis with both heritable and environmental factors contributing to onset and severity. In addition to a disfiguring skin inflammation, approximately 10-40% of psoriasis patients suffer from destructive joint involvement. Previously, we reported that the CD18 hypomorphic PL/J mouse carrying a mutation resulting in reduced expression of...

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