www.thelancet.com Vol 384 October 11, 2014 1345 as 1–2% chlorhexidine in isopropyl alcohol, but we agree with Maiwald and colleagues that adequate studies to support or reject this hypothesis have not yet been done. Chlorhexidine in an alcoholic solution, however, is clearly superior to povidone-iodine for prevention of vascular catheter-related bloodstream infec tion. Maiwald and colleagues ha...

AIMS This study examined the difference in autonomic modification (AM) and its effect on paroxysmal atrial fibrillation (PAF) recurrence between segmental pulmonary vein isolation (S-PVI) and circumferential PVI (C-PVI). METHODS AND RESULTS Successful S-PVI or C-PVI with a basket catheter was achieved in 120 consecutive PAF patients. Serial 24 Holter-recordings were obtained before, immediate...

OBJECTIVES The aim of this study was to investigate whether the combination of conventional pulmonary vein isolation (PVI) by circumferential antral ablation with ganglionated plexi (GP) modification in a single ablation procedure, yields higher success rates than PVI or GP ablation alone, in patients with paroxysmal atrial fibrillation (PAF). BACKGROUND Conventional PVI transects the major l...

Background: The C-terminus of pVI activates the adenovirus proteinase. pVI escorts hexon into the nucleus. Results: pVI binds tightly to DNA independent of sequence, Kd = 46 nM. pVI binds tightly to hexon, Kd = 1.1 nM. Conclusion: DNA binding of pVI is first step in the activation of adenovirus proteinase. Significance: Links pVI, hexon, viral DNA and the adenovirus proteinase in virion maturat...

BACKGROUND Data regarding the long-term efficacy of atrial fibrillation (AF) ablation are still lacking. METHODS AND RESULTS Two hundred four consecutive patients symptomatic for paroxysmal or persistent/permanent AF were randomly assigned to 2 different ablation schemes: pulmonary vein isolation (PVI) and PVI plus left linear lesions (LL). Primary end point was to assess the maintenance of s...

Objective Mechanisms of pulmonary vein isolation (PVI) for atrial fibrillation remain controversy. This study aimed to investigate the impact of PVI on vagal modulation to atria. Methods Eighteen adult mongrel dogs under general anesthesia were randomly divided into two groups. Bilateral cervical sympathovagal trunks were decentralized and sympathetic effects was blocked by metoprolol administr...

INTRODUCTION Adjunctive complex fractionated atrial electrograms (CFAE) ablation or ganglionated plexi (GP) ablation have been proposed as new strategies to increase the elimination of AF, but the difference between CFAE/GP ablation and pulmonary vein isolation (PVI), as well as the combined effect of CFAE/GP plus PVI ablation were unclear. This meta-analysis was designed to determine whether a...

Pairwise Variability Index (PVI) gives a measure of the amount of variation between adjacent speech units, making it possible to arrange languages in a continuum of relative variability. In the present study, the PVI of Estonian speakers living in Sweden for over 60 years was compared to the PVI of Swedish and of Estonian spoken in Estonia. The results show that (1) PVI is significantly higher ...

BACKGROUND Atrial fibrillation (AF) commonly occurs in association with chronic kidney disease (CKD), resulting in adverse outcomes. Combining pulmonary vein isolation (PVI) and renal sympathetic denervation (RSD) may reduce the recurrence of AF in patients with CKD and hypertension. We considered that RSD could reduce the recurrence of AF in patients with CKD by modulating sympathetic hyperact...