Article history: Received 7 May 2012 Received in revised form 6 November 2012 Accepted 9 November 2012 Available online 17 November 2012 JEL classification: D81 Q40 G11

The present study aimed to identify a new selective glucocorticoid receptor (GR) ligand for the treatment of chronic inflammation in type 2 diabetes mellitus. The IN Cell Analyzer 1000 platform was employed to screen for compounds that may promote GR nuclear translocation. A mammalian two-hybrid system and transactivation assay-were used to analyze the selected GR ligands and evaluate their act...

We have characterized the conformational ensembles of polyglutamine Qn peptides of various lengths n (ranging from 6 to 40), both with and without the presence of a C-terminal polyproline hexapeptide. For this, we used state-of-the-art molecular dynamics simulations combined with a novel statistical analysis to characterize the various properties of the backbone dihedral angles and secondary st...

Wkh VRP dojrulwkp zdv lqwurgxfhg e| Nrkrqhq lq 4<;4 dqg kdv ehhq wkh irfxv ri d vl}hdeoh dprxqw ri dwwhqwlrq lq wkh vflhqwl f frppxqlw| vlqfh wkhq1 Qx0 phurxv dssolfdwlrqv kdyh ehhq sursrvhg +vhh Nrkr0 qhq ^4<<8` iru d uhsuhvhqwdwlyh olvw ri wkhp, dqg wkh wkhruhwlfdo surshuwlhv kdyh ehhq fduhixoo| vwxglhg +vhh Frwwuhoo/ Iruw ) Sdjëv ^4<<;` iru d uhylhz ri wkh hvwde0 olvkhg uhvxowv xs wr qrz,1 K...

Age-dependent neurodegenerative diseases progressively form aggregates containing both shared components (e.g., TDP-43, phosphorylated tau) and proteins specific to each disease. We investigated whether diverse neuropathies might have additional aggregation-prone proteins in common, discoverable by proteomics. Caenorhabditis elegans expressing unc-54p/Q40::YFP, a model of polyglutamine array di...

Promoting investments in energy-saving technologies is an important means for achieving environmental goals. Empirical evidence on success conditions of associated policies, however, is scarce. Based on a survey among Dutch firms, this paper sets out to identify the factors that determine the investment behaviour of firms, their attitude towards various types of energy policy, and their respons...

Coherent anti-Stokes Raman scattering (CARS) microscopy is applied for the first time for the evaluation of the protein secondary structure of polyglutamine (polyQ) aggregates in vivo. Our approach demonstrates the potential for translating information about protein structure that has been obtained in vitro by X-ray diffraction into a microscopy technique that allows the same protein structure ...

We consider a model of resource dependence where only the seller knows the resource reserve. The model captures phenomena such as trust in the relationship and “bribing” for continuation through generous supplies. It also explains supply shocks in equilibrium: privately informed sellers have incentives to reveal their types too late through a supply disruption after which their exploit the cons...

We study transitions between nonrenewable and renewable energy forms at di!erent development stages of an economy. It is shown that in the historical context the emphasis on energy production may evolve from renewables to nonrenewables and back to renewables. Typically both energy forms are used simultaneously. Along the equilibrium path, nonrenewable resource consumption may increase and their...

In this paper we propose a jump-diffusion type model which recovers the main characteristics of electricity spot price dynamics in the Nordic market, including seasonality, mean-reversion and spiky behavior. We show how the calibration of the market price of risk to actively traded futures contracts allows for efficient valuation of Nord Pool's Asian-style options written on the spot electricit...