Visual modeling paradigm is known for a number of decades already but still vast majority of software engineers prefer traditional programming to automated code generation from visual models. In this paper we discuss several ways to make modeling using diagrams more usable for industrial software development. Specialized domain-specific visual languages could be used to make models clearer and ...

mdma generally known as ecstasy, have deleterious effects on the serotonergic neurotransmitter system. recent findings suggest that the liver and brain are major target organs of mdma-related toxicities. although most research is being dynamically performed on brain, however, the molecular mechanisms by which mdma elicits adverse effects in both organs are poorly undrestood.the present study wa...

background 3-4methylenedioxymethamphetamine (mdma) is a synthetic and psychoactive drug, which is known popularly as ecstasy and has toxic effects on human organs. objectives considering the potential toxic interaction, this study was performed to quantify the expression of bax and bcl2 genes in mdma-induced hepatotoxicity on rat liver. subsequently, we evaluated pentoxifylline as a possible pr...

ABSTRACT Objective This research was conducted as a prospective, self-controlled, eight-week clinical trial to investigate the effect of kefir consumption on lipid profile individuals with normal and dyslipidemic properties. Methods Kefir microorganisms given volunteer subjects were determined using classical microbial count methods qReal-Time Polymerase Chain Reaction. The study carried out 23...

Rab7 GTPases are involved in membrane trafficking in the late endosomal/lysosomal pathway. In Paramecium octaurelia Rab7a and Rab7b are encoded by paralogous genes. Antipeptide antibodies generated against divergent C-termini recognize Rab7a of 22.5 kDa and Rab7b of 25 kDa, respectively. In 2D gel electrophoresis two immunoreactive spots were identified for Rab7b at pI about 6.34 and about 6.18...