نتایج جستجو برای: quinolones

تعداد نتایج: 3627  

Journal: :jundishapur journal of microbiology 0
iraj sedighi department of pediatric, faculty of medicine, hamadan university of medical sciences, hamadan, ir iran mohammad reza arabestani department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, ir iran; brucellosis research center, hamadan university of medical sciences, hamadan, ir iran ali rahimbakhsh department of microbiology, faculty of basic and medical sciences, islamic azad university of zanjan, zanjan, ir iran zahra karimitabar department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, ir iran mohammad yousef alikhani department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, ir iran; brucellosis research center, hamadan university of medical sciences, hamadan, ir iran; brucellosis research center, hamadan university of medical sciences, hamadan, ir iran. tel: +98-8118380755, fax: +98-8118380130

conclusions ctx-m was the most prevalent esbl genotype in uropathogenic e. coli (upec) isolated from uti. in addition, a high frequency of qnr genes among esbl-producing e. coli was identified in this study. in order to avoid treatment failures, we recommend using phenotypic and molecular methods to diagnose these enzymes and qnr genes. results the highest sensitivity was seen to imipenem (96.7...

Journal: :Chemical Science 2023

A practical approach for preparing 3,4-fused 2-quinolones has been disclosed. The Rh( iii )-catalyzed highly selective alkenyl C–H activation/annulation of 4-amino-2-quinolones was achieved via an unprecedented reversible alkyne insertion.

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005
Vincent T Andriole

The quinolone class of antimicrobial agents has generated considerable interest since its discovery >40 years ago. Substantial progress has been made in our understanding of the molecular mechanisms of the action of quinolones against pathogenic bacteria, the induction of resistance to quinolones in these organisms, and the potential of each quinolone compound to induce toxicity in treated pati...

A.R Foromadi M Rajaei M.H Moshafi

quinolones are broad-spectrum antibacterial agents.they have many clinical uses which are increasing.quinolones exert antibacterial activity primarily by inhibiting bacterial DNA gyrase.the inhibition of DNA gyrase by the quinolones are greatly influenced by the nature of the C-7 substituent on the quinolones molecule.substitution of bulky functional groupd is also possible in C-7 position.furt...

Journal: :Canadian Journal of Infectious Diseases 1992

Journal: :The European respiratory journal 2007
I I Siempos G Dimopoulos I P Korbila K Manta M E Falagas

The comparative effectiveness and safety of macrolides, quinolones and amoxicillin/clavulanate (A/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study. PubMed, Current Contents and the Cochrane Central Register of Controlled Trials were searched to identify relevant randomised controlled trials (RCTs). In total, 19 R...

Journal: :The Journal of antibiotics 1998
K A Dekker T Inagaki T D Gootz L H Huang Y Kojima W E Kohlbrenner Y Matsunaga P R McGuirk E Nomura T Sakakibara S Sakemi Y Suzuki Y Yamauchi N Kojima

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.

Journal: :Molecules 2016
Abdul Naeem Syed Lal Badshah Mairman Muska Nasir Ahmad Khalid Khan

Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available for clinical consumption in 1962 and was used mainly for urinary tract infections caused by Escherichia coli and other pathogenic Gram-negative bacteria. Recently, significant work has been carried out to synthesize n...

Journal: :Antimicrobial agents and chemotherapy 2001
M Takei H Fukuda R Kishii M Hosaka

The antibacterial activities and target inhibition of 15 quinolones against grlA and gyrA mutant strains were studied. The strains were obtained from wild-type Staphylococcus aureus MS5935 by selection with norfloxacin and nadifloxacin, respectively. The antibacterial activities of most quinolones against both mutant strains were lower than those against the wild-type strain. The ratios of MICs...

2017
Jinghua Wang Haiyang Xu Pan Liu Mingxian Li

The purpose of this study was to compare the relative efficacy and safety of different antibiotic drugs and recommend superior regimens in the treatment of bronchitis. With respect to the antibiotic comparisons against quinolones in terms of intention-to-treat patients, we concluded that quinolones had advantages over placebo, β-lactams, sulfonamides, and double β-lactams. Concerning treatment ...

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