background: recently, different investigators have studied the possibility of radiation therapy in restenosis prevention and have shown promising results. in this study a unique radioactive source for intra vascular brachytherapy (ivbt) was investigated. the two-dimensional dose distribution in water for a 32p ivbt stent has been calculated. the pure beta emitter source 32p has been coated on p...

BACKGROUND Recent reports demonstrate that intracoronary radiation affects not only neointimal formation but also vascular remodeling. Radioactive stents and catheter-based techniques deliver radiation in different ways, suggesting that different patterns of remodeling after each technique may be expected. METHODS AND RESULTS We analyzed remodeling in 18 patients after conventional stent impl...

BACKGROUND Radioactive stents have been reported to reduce in-stent neointimal thickening. An unexpected increase in neointimal response was observed, however, at the stent-to-artery transitions, the so-called "edge effect." To investigate the factors involved in this edge effect, we studied stents with 1 radioactive half and 1 regular nonradioactive half, thereby creating a midstent radioactiv...

Background—Radioactive stents have been reported to reduce in-stent neointimal thickening. An unexpected increase in neointimal response was observed, however, at the stent-to-artery transitions, the so-called “edge effect.” To investigate the factors involved in this edge effect, we studied stents with 1 radioactive half and 1 regular nonradioactive half, thereby creating a midstent radioactiv...

BACKGROUND Edge restenosis is a major problem after radioactive stenting. The cold-end stent has a radioactive mid-segment (15.9 mm) and non-radioactive proximal and distal 5.7 mm segments. Conceptually this may negate the impact of negative vascular remodelling at the edge of the radiation. METHOD AND RESULTS ECG-gated intravascular ultrasound with three-dimensional reconstruction was perfor...

BACKGROUND We compared the effectiveness of self-expanding metal stent alone vs. radioactive stent embedded with 125I seeds implantation insertion in patients of inoperable esophageal squamous cell cancer combined with malignant esophageal stenosis. METHODS We studied two groups of patients with stenosis attribute to inoperable esophageal squamous cell carcinoma. Group A had placed self-expan...

AIMS This study is the contribution by the Thoraxcenter, Rotterdam, to the European(32)P Dose Response Trial, a non-randomized multicentre trial to evaluate the safety and efficacy of the radioactive Isostent in patients with single coronary artery disease. METHODS AND RESULTS The radioactivity of the stent at implantation was 6--12 microCi. All patients received aspirin indefinitely and eith...

BACKGROUND Experimental studies have demonstrated that 32P radioactive stents reduce neointimal formation at 28 days in porcine iliac and coronary arteries. Our objective was to determine the long-term dose-response effects of 1.0- to 12.0-microCi 32P radioactive stents in a porcine atherosclerotic coronary model. METHODS AND RESULTS Control (n=19) and 1.0- to 12.0-microCi 32P radioactive (n=...

Background—Experimental studies have demonstrated that P radioactive stents reduce neointimal formation at 28 days in porcine iliac and coronary arteries. Our objective was to determine the long-term dose-response effects of 1.0to 12.0-mCi P radioactive stents in a porcine atherosclerotic coronary model. Methods and Results—Control (n519) and 1.0to 12.0-mCi P radioactive (n543) stents (total, n...

Background—A high restenosis rate has been reported at the edges (“edge restenosis”) of P radioactive stents with an initial activity level of 3 to 12 mCi. This edge effect might be due to balloon injury and to a low dose of radiation at the stent margins. The aim of this study was to evaluate whether the implantation of P radioactive stents with a higher activity level (12 to 21 mCi) combined ...