background: there is not enough information about theeffects of heat stress and photoperiod on different lobes structure.objectives: the present study aims at determining thehistological changes and the rate of changes in each lobes of ratprostate, affected by photoperiod changes and heat stress.methods:to this end, 15 adult male wistar rats were divided tothree groups: 1. the control group in ...

growth of the prostate gland, also development of benign prostatic hyperplasia (BPH) is an androgen-dependent functions. Testosterone plays a major role in the prostate gland. Rat prostate gland is one of the most widely used models of animals in investigation. The rat prostate gland consisted of five lobes; the ventral, anterior, dorsal, lateral type 1 and latteral type 2. The goal of present ...

benign prostatic hyperplasia (bph) is a common disease in human that gradual overgrowth of the prostate gland leads to impinge on the urethra with impairment in urinary function. numerous plants improve uncontrolled growth of the prostate gland and improve urinary tract symptoms associated with bph. in this study, 25 healthy adult male wistar rats were divided randomly in five groups: g1 (contr...

Figure Legend: Figure 1 Prostate Inflammation. Arrows indicate neutrophils passing through the acinar mucosa in a male F344/N rat from a chronic study. Figure 2 Prostate Inflammation. Suppurative inflammation of the prostate in a male F344/N rat from a chronic study. Figure 3 Prostate Inflammation. Inflammation of the prostate associated with epithelial degeneration in a male F344/N rat from a ...

Background: Rat prostate gland which is used in various investigation has considerable morphological differences with other mammals. There are few reports about its structure. So, this study was carried on for determining of histomorphological structure of rat prostate. Materials and Methods: Five healthy adult male rats with average weight 20 ± 180 g and approximately 3 - 3.5 months age were s...

Background: The increase of stress following the technological improvements appears to be an important factor that causes organs disorders like genital system. Therefore the present study was conducted to investigate the effects of chronic multiple sequential stress on rat prostate. Materials and Methods: 18 Wistar rats were divided randomly into two equal groups. In animals under stress, the m...

BACKGROUND Androgens and paracrine signaling from mesenchyme/stroma regulate development and disease of the prostate, and gene profiling studies of inductive prostate mesenchyme have identified candidate molecules such as pleiotrophin (Ptn). METHODS Ptn transcripts and protein were localized by in situ and immunohistochemistry and Ptn mRNA was quantitated by Northern blot and qRT-PCR. Ptn fun...

The ALP1 [aci-reductone dioxygenase (ARD)-like protein 1] gene was identified in a comprehensive cDNA subtraction aimed at identifying genes regulated by androgens in the rat ventral prostate. ALP1 is homologous to the ARD/ARD' that were discovered in Klebsiella pneumoniae as enzymes that have the same polypeptide sequence and differ only in their metal content. This family of proteins is evolu...

Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating changes in the tumor-bearing organ, for example growth of the vasculature, an altered extracellular matrix, and influx of inflammatory cells. To investigate this response further, we compared prostate morphology and the gene expression profile of tumor-bearing normal rat prostate tissue (termed t...