the immunosuppressive effect of antimacrophage serum (ams) on the primary immune response of mice to sheep red blood cells (srbc) was studied. ams, given before a small dose of antigen, abrogated the immune response. transplantation of normal, galss-adherent macrophages enabled ams-treated animals to respond to srbc, while administration of lymph node lymphocytes did not reveres ams - induced i...

n engl j med 364;4 nejm.org january 27, 2011 376 The remarkable advances in molecular and cell biology over the past half century have revealed layer upon layer of biologic complexity. It has even been suggested that we are reaching a stage at which further progress may be beyond the scope of human imagination, that these branches of science — like physics in its endless search for a unifying t...

Exposure to toxic chemicals may result in alterations of red cell function. In certain cases, the toxic effect requires a genetic predisposition and thus affects only a restricted number of individuals; in other instances, the toxic effect is exerted on the hematopoietic system of every person. Glucose-6-phosphate dehydrogenase deficiency is probably the most widespread genetic disorder. It is ...

During exercise the cardiovascular system has to warrant substrate supply to working muscle. The main function of red blood cells in exercise is the transport of O2 from the lungs to the tissues and the delivery of metabolically produced CO2 to the lungs for expiration. Hemoglobin also contributes to the blood's buffering capacity, and ATP and NO release from red blood cells contributes to vaso...

amyloidoma or amyloid tumor is a tumor-like localized deposit of amyloid encountered occasionally in association with multiple myeloma, various chronic inflammatory diseases and primary amyloidosis. amyloid tumors unassociated with plasmacytoma or other disease are extremely rare in soft tissues and few cases in various situations have been reported. histologic examination discloses amorphous e...

Detection of ABO blood groups through agglutination is the basis of pre-transfusion testing. However, weak agglutination reactions may be obtained with reagent antibodies and are a result of weak expression of A and B antigens on red blood cell surface which may cause a discrepancy in blood group typing. Here, we report a donor which showed discrepancy between red blood cells (forward) and seru...

Blood cells are key component of organism for their survival and has profound role in defence mechanism of invertebrates similarly in bivalve species, the key role is healing wound and nutrients transportation. The Anadara antiquata is unique because of haemoglobin in their haemolymph and it is commonly found in Pakistani coast.  Present investigation revealed three types of Blood cells, namel...

These experiments were made to obtain more information about the surface of the red blood cell. Since "surface" means different things to different people, we shall define our meaning now. Strictly speaking, the surface studied by electrophoresis is the surface of shear between the cell (moving in the electric field) and the surrounding medium, for it is the potential at this surface which is t...

Erythrocytes from a burned patient show a temporal sequence of morphological changes. Immediate severe changes occur which are followed by a transient phase only of less abnormal morphology. Heating whole blood in vitro to 49 degrees C instead of 50 degrees C does not show the expected dose response curve. Heating whole blood in vitro to 50 degrees C induces progressive morphological changes. F...