In this study a 3-factor, 3-level Box-Behnken design was used to prepare optimized docetaxel (DTX) loaded pegylated poly lactide-co-glycolide (PEG-PLGA) NPs with polymer concentration (X1), drug concentration (X2) and ratio of the organic to aqueous solvent (X3) as the independent variables and particle size (Y1), poly dispersity index (PDI) (Y2) and drug loading (Y3) as the responses. The cyto...

Tablets containing metoprolol succinate and Compritol®888ATO in the ratio of 1:2 yielded the desired sustained release profile in phosphate buffer pH 6.8 when evaluated using USP type II paddle apparatus and was selected as the optimized formulation. Robustness of optimized formulation was assessed by studying the effect of factors like varying source of metoprolol succinate and Compritol®888AT...

a controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. using compritol 888 ato (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the solid dispersions were investigated. pectin, a polysaccharide, was used as bacterial dependent polymer for colon targeting. the m...

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

background: progress in the field of biology and biochemistry has led to the discovery of numerous bioactive peptides and proteins in the last few decades. delivery of therapeutic proteins/peptides has received a considerable amount of attention in recent years. methods: in this study, a two-step desolvation method was used to produce biodegradable hydrophilic gelatin nanoparticles (gnp) as a d...

the most frequent adverse effects of indomethacin like other nsaids are gastro–intestinal and central nervous system disturbances. extended release or enteric release formulations minimize these symptoms. the objective of this study was to develop an extended release pellet formulation of indomethacin by the centrifugation (rotary fluid bed granulation) or powder layering method. layered, nonpa...

the purpose of this study was to prepare and characterize nimodipine loaded microspheres using ethyl cellulose (ec) as a carrier polymer through an emulsion solvent evaporation method. these evaluations characterized the pattern of drug release from prepared microspheres. nimodipin loaded microspheres were prepared using an emulsification solvent evaporation method. the effect of process variab...

The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder us...