Typically disease-causing CAG/CTG repeats expand, but rare affected families can display high levels of contraction of the expanded repeat amongst offspring. Understanding instability is important since arresting expansions or enhancing contractions could be clinically beneficial. The MutSβ mismatch repair complex is required for CAG/CTG expansions in mice and patients. Oddly, by unknown mechan...

In this paper we consider a system consisting of a supplier with a single processing unit, a repair center, and a retailer with Poisson demand. We assume that the retailer applies one-for-one ordering policy with backorders for his inventory control. The retailer’s orders form a queue in the supplier processing unit. We also assume that a certain fraction of the products produced by the supplie...

Objectives: Ceramics have advantages such as optimal esthetics and biocompatibility. However, in the oral environment, they are subjected to high levels of stress due to masticatory forces, saliva, thermal changes and alterations of pH, which increase their risk of fracture. Since replacement of these restorations is costly and time-consuming, composite resin is often used for intraoral repair ...

Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...

Markov model of multi-component machining system comprising two unreliable heterogeneous servers and mixed type of standby support has been studied. The repair job of broken down machines is done on the basis of bi-level threshold policy for the activation of the servers. The server returns back to render repair job when the pre-specified workload of failed machines is build up. The first (seco...

Introduction: The pericranial flaps' benefits have been described in many otolaryngologic, maxillofacial and plastic surgery literature. The benefits ar e due to the pericranial flaps unique characteristics including good flexibility and mobility, very rich blood supply from several arterial sources and access to sufficient bulk of the flap without any need for distant surgical sites. Using pe...

Introduction: Since 1954, after the first surgical repair of tetralogy of Fallot (TOF), several innovations have occurred in cardiac surgery, especially in children. One stage complete repair of TOF is currently possible even in infancy; however, complications such as hypoxemia, arrhythmia, cardiac dysfunction, sudden death, and valvular disorders may happen. In this study, we evaluated the res...

Laryngotracheal and tracheobronchial injuries are uncommon, and their successful diagnosis and management often require a high level of expertise. This paper aimed at retrospective analysis of a thoracic surgeon's experience in the diagnosis and management of traumatic injuries to the larynx, trachea and major bronchi. Forty one patients with major airway trauma were managed from March 1994 to ...