نتایج جستجو برای: reperfusion injury mesenchymal stem cells rats

تعداد نتایج: 2000041  

Kheirandish M, Rafieemehr H, Soleimani M,

Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...

2014
Saverio La Francesca Anthony E Ting Jason Sakamoto Jessica Rhudy Nicholas R Bonenfant Zachary D Borg Fernanda F Cruz Meagan Goodwin Nicholas A Lehman Jennifer M Taggart Robert Deans Daniel J Weiss

BACKGROUND Primary graft dysfunction (PGD) is a significant cause of early morbidity and mortality following lung transplantation. Improved organ preservation techniques will decrease ischemia-reperfusion injury (IRI) contributing to PGD. Adult bone marrow-derived adherent stem cells, including mesenchymal stromal (stem) cells (MSCs) and multipotent adult progenitor cells (MAPCs), have potent a...

Journal: :iranian journal of basic medical sciences 0
mohammad reza baghaban eslaminejad stem cell department, royan institute, tehran, iran leila taghiyar stem cell department, royan institute, tehran, iran

objective articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. on the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. little is known about the presence of mesenchymal stem cells in articular cartilage tissue. this subject is investigated in the present study. materials and methods articula...

Journal: :iranian journal of basic medical sciences 0
fateme zhaleh blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran fatemeh amiri blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran mohammad mohammadzadeh-vardin department of anatomical sciences and pathology, school of medicine, ardabil university of medical sciences, ardabil, iran marzie bahadori blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran mitra dehghan harati school of medicine, shahid sadoughi university of medical sciences, yazd, iran mehryar habibi roudkenar blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran

objective(s):recently cell therapy is a promising therapeutic modality for many types of disease including acute kidney injury (aki). due to the unique biological properties, mesenchymal stem cells (mscs) are attractive cells in this regard. this study aims to transplant mscs equipped with nuclear factor e2-related factor 2 (nrf2) in rat experimental models of acute kidney and evaluate regenera...

Objective(s): Intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. Materials and Methods: Animals were randomized into three gro...

Asghar Ebrahimi Bahareh Laribi Mahdi Tondar Mehdi Mehdizadeh, Mehrdad Bakhtiary Mohammad Taghi Joghataei, Mohsen Marzban, Navid Modiry Samideh Khoei, Seyed Jafar Hashemian, Soraya Mehrabi Vahid Pirhajati Mahabadi,

Objective(s) Clinical studies of treating traumatic brain injury (TBI) with autologous adult stem cells led us to examine the impression of a combination therapy. This was performed by intravenous injection of human umbilical cord matrix stem cell (hUCMSC-Wharton,s jelly stem cell) with bone marrow cell mobilized by granulocytecolony stimulating factor (G-CSF) in rats injured with cortical com...

Fateme Zhaleh, Fatemeh Amiri, Marzie Bahadori Mehryar Habibi Roudkenar Mitra Dehghan Harati mohammad Mohammadzadeh-Vardin Sasan Saki,

Objective(s):Recently cell therapy is a promising therapeutic modality for many types of disease including acute kidney injury (AKI). Due to the unique biological properties, mesenchymal stem cells (MSCs) are attractive cells in this regard. This study aims to transplant MSCs equipped with nuclear factor E2-related factor 2 (Nrf2) in rat experimental models of acute kidney and evaluate regenera...

Journal: :Acta cirurgica brasileira 2017
Sylvio Valença de Lemos Isabela Galvão Vianna Yara Marcondes Machado Castiglia Marjorie de Assis Golim Aparecida Vitória Gonçalves de Souza Lídia Raquel de Carvalho Elenice Deffune Paulo do Nascimento Norma Sueli Pinheiro Módolo Pedro Thadeu Galvão Vianna

Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5...

Journal: :Acta cirurgica brasileira 2014
André Luiz Pires de Freitas Marcelo de Oliveira e Silva Priscilla Martin Keiko Matsumoto Sang Won Han Lydia Masako Ferreira

PURPOSE To investigate the experimental model for obtaining adipose tissue, isolation, characterization of mesenchymal stem cells and evaluation of their distribution in the tram flap in rats. METHODS Five rats of Wistar were randomly assigned to two groups. In group I, three animals underwent removal of adipose tissue in the groin procedure to establish the experimental model and obtain a ce...

Journal: :international journal of pediatrics 0
zahra mohammadi faculty of medicine, mashhad university of medical sciences, mashhad, iran. jalil tavakol afshari immunology research center. mohammad reza keramati cancer molecular pathology research center. daryoush hamidi alamdari stem cell & regenerative medicine research group, department of clinical biochemistry. meysam ganjibakhsh faculty of medicine, mashhad university of medical sciences, mashhad, iran. azam moradi zarmehri faculty of medicine, mashhad university of medical sciences, mashhad, iran.

introduction: mesenchymal stem cells can be isolated from adult tissues, such as the adipose tissue, or other sources. among all these sources, adipose tissue because of easy access, and placenta due to its immunomodulatory properties, in addition to another useful properties, were attracted more attention to themselves. isolation and comparing these two different sources can help us for access...

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