نتایج جستجو برای: reperfusion injury mesenchymal stem cells rats

تعداد نتایج: 2000041  

Journal: :Biomedicine & Pharmacotherapy 2021

Indolamine 2,3-dioxygenase (IDO), an enzyme that catalyses the metabolism of tryptophan, may play a detrimental role in ischemia-reperfusion injury (IRI). IDO can be inhibited by 1-methyl-tryptophan, which exists D (D-MT) or L (L-MT) isomer. These forms show different pharmacological effects besides inhibition. Therefore, we sought to investigate whether these isomers protective renal IRI, eith...

Journal: :international journal of hematology-oncology and stem cell research 0
khushnuma cooper regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india. viru shah regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india. nupur sapre regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india. ekta sharma regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india. chetna mistry regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india. chandra viswanathan regenerative medicine group, reliance life sciences pvt. ltd., dhirubhai ambani life sciences centre, r-282, ttc area of midc, thane-belapur rd. rabale, navi mumbai - 400701, maharashtra, india.

background: umbilical cord tissue is a very rich source of mesenchymal stem cells. instead of discarding this source we are banking the tissue along with cord blood for possible future cell based applications. the cord tissue needs to be transported and stored properly in order for it to be good enough for cell isolation at a later date. in this paper we have carried out a validation study to d...

Rajabi, Hamid, Dehghani Nazhvani, Seifollah , Mehrabani , Davood , Norouzian , Manijeh , Sheikhani Shahin , Homa ,

The aim of this study was to the effect of aquatic activity and alogenic bone marrow derived mesenchymal stem cells fortified with Platelet-Rich Plasma in treatment of Achilles tendon in rat.  74 Sprague-Dawley rats were selected and tendon injury was formed in 69 of them. Subsequently, these rats were randomly divided into 8 groups and 5 rats which were without any injuries were chosen as the ...

ژورنال: پژوهش در پزشکی 2014
بیات, محمد, خیرجو, راضیه, رجبی بذل, معصومه, محسنی فر, ژاله, پیریایی, عباس, گنجی, رسول,

Abstract Background: Diabetes is a metabolic chronic disorder that makes it difficult to heal wounds because of its complications. To this point, many studies on the use of mesenchymal stem cells in wound healing process particularly diabetic ulcers have been done. In this study, we evaluate the impact of mesenchymal stem cells-derived conditioned medium (MSC-CM) on diabetic wound strength. Mat...

Abbas Piryaei, Arash Zaminy, Mohammad Ali Shokrgozar, Mohammad Hassan Heidari, Mohsen Noroozian, Yousef Sadeghi,

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

2011
Hiroyuki Kanazawa Yasuhiro Fujimoto Takumi Teratani Junji Iwasaki Naoya Kasahara Kouji Negishi Tatsuaki Tsuruyama Shinji Uemoto Eiji Kobayashi

BACKGROUND Ischemia-reperfusion (I/R) injury associated with living donor liver transplantation impairs liver graft regeneration. Mesenchymal stem cells (MSCs) are potential cell therapeutic targets for liver disease. In this study, we demonstrate the impact of MSCs against hepatic I/R injury and hepatectomy. METHODOLOGY/PRINCIPAL FINDINGS We used a new rat model in which major hepatectomy wi...

Journal: :trauma monthly 0
kamal seyed foroutan department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran; department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran. tel: +98-2188890889 ali khodarahmi department of plastic surgery, bahonar hospital, kerman university of medical sciences, kerman, ir iran hootan alavi department of plastic surgery, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran sepehr pedram veterinary faculty, hazrat fatemeh hospital, iran university of medical sciences, tehran, ir iran mohamad reza baghaban eslaminejad department of stem cells and developmental biology, cell science research center, royan institute for stem cell biology and technology, acecr, tehran, ir iran sima bordbar department of stem cells and developmental biology, cell science research center, royan institute for stem cell biology and technology, acecr, tehran, ir iran

conclusions the results of this study showed that the meticulous microsurgical nerve repair, which was performed using the vein tubulization induced significantly better sciatic nerve regeneration. however, the addition of bone marrow mesenchymal stem cell to vein conduit failed to promote any significant changes in regeneration outcome. results all animals tolerated the surgical procedures and...

Journal: :گوارش 0
negin raei saeid latifi-navid saber zahri

helicobacter pylori was the main cause of gastric cancer (gc) in all over the world that results in intestinal- and diffuse-type carcinoma. infection by this bacterium remains chronic for a long time. in vitro studies have highlighted the role of stem cells in gc. h. pylori infection results in tissue injury and the adult/tissue stem cells subsequently start to replace the dead cells. the genet...

Ali Gorji, Ali Hasani Dooghabadi, Ali Jahanbazi Jahan Abad, Arezou Es'haghabadi, Farzin Naseri, Ghazale Biglari, Mohammad Moein Shirzad, Sajad Sahab Negah,

Traumatic brain injury is one of the major causes of brain function impairments and surgery is involved in the treatment program of many cases although it cannot rescue the brain functions completely and is confined to reduce the second injury .in this study we aimed to investigate the effects of mesenchymal stem cells encapsulated in RADA1- GGS IKVAV, surgically injected into the lesion site. ...

Journal: :International journal of clinical and experimental medicine 2015
Xiaowu Hu Junjie Yang Ying Wang You Zhang Masaaki Ii Zhenya Shen Jie Hui

BACKGROUND Cell-based angiogenesis is a promising treatment for ischemic diseases; however, survival of implanted cells is impaired by the ischemic microenvironment. In this study, mesenchymal stem cells (MSCs) for cell transplantation were preconditioned with trimetazidine (TMZ). We hypothesized that TMZ enhances the survival rate of MSCs under hypoxic stimuli through up-regulation of HIF1-α. ...

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