background: retinol?binding protein 4 (rbp4) is known to regulate lipid and glucose metabolism and insulin resistance. the influences of rbp4 on metabolic syndrome (ms) are still unclear. the purpose of this study is to evaluate the association between serum levels of rbp4 and ms components in first?degree relations of type 2 diabetic patients. materials and methods: this cross?sectional study ...

background: serum levels of lipocalin 2 (lcn 2) and retinol-binding protein-4 (rbp 4), increase in type 2 diabetes mellitus (t2dm). we sought to determine whether serum lcn 2 and rbp 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. methods: forty-five type 2 diabetic patients from iranian diabetic association in tehran, iran in 2013 were randomly rec...

objective(s):psoriasis is an autoimmune disease that appears on the skin. although psoriasis is clinically and histologically well characterized, its pathogenesis is unknown in detail. the aims of this study were to evaluate the proteome of psoriatic patients' sera and to compare them with those of normal healthy human to find valuable biomarkers. materials and methods: in a case-control s...

Hypothyroidism and hyperthyroidism are prevalent endocrine diseases.These have significant implications for lipid synthesis, mobilization, metabolism. Retinol-binding protein 4 is a new adipokine implicated in some physiological pathological processes, such as metabolic disorders. Its elevation aids the diagnosis of thyroid problems. The present study includes 60 women with diseases; 30 them hy...

the established risk factors for cardiometabolic disease. However, the alarming increase in overweight and obesity in children and the trajectory and reach of related comorbidities such as cardiometabolic disease challenge us to identify potential modifiable pathways that will have sufficient impact to turn these around. In this context, this study is a step in the direction of identifying uniq...

Retinol, an established topical ingredient for improving signs of photo-aging, is often limited in concentration due to the potential low-level visible and sensory irritation. A new anhydrous, 0.5% stabilized retinol serum was developed, balancing bioactivity tolerability. This patented formula uses Relative Polarity Index (RPI) between skin, retinol, emollient ratios, allowing controlled bio-d...