Safety cases offer a means for communicating information about the system safety among the system stakeholders. Recently, the requirement for a safety case has been considered by regulators for safety-critical systems. Adopting safety cases is necessarily dependent on the value added for regulatory authorities. In this work, we outline a structured approach for assessing the level of sufficienc...

In many cases, crashes at intersections account for over 50% of all urban road accidents. The need to reduce these crashes has fostered considerable research on the development and evaluation of traffic safety at intersections. This paper introduces a micro-level behavioral method for estimating crash potential at signalized and unsignalized intersections for different traffic characteristics. ...

OBJECTIVE Angiotensin II is an endogenous hormone with vasopressor and endocrine activities. This is a systematic review of the safety of IV angiotensin II. DATA SOURCES PubMed, Medline, Scopus, and Cochrane. STUDY SELECTION Studies in which human subjects received IV angiotensin II were selected whether or not safety was discussed. DATA EXTRACTION In total, 18,468 studies were screened b...

OBJECTIVES To assess the effect of a temporary interruption in subcutaneous (SC) abatacept on immunogenicity, safety and efficacy in patients with active rheumatoid arthritis despite methotrexate in a phase III trial. METHODS Following a 12-week open-label introduction (period I; intravenous abatacept loading dose and weekly fixed-dose SC abatacept 125 mg), patients were randomised 2:1 to dou...

System safety research has a weakness in terms of evaluation. In particular, the field has a poor track record for applying appropriate research methods to the questions we wish to answer, and for evaluating the answers in a convincing way. Given changes in government and public attitudes to research funding, this will be an increasing concern in the near future. In this paper, we define a taxo...

Safety cases are now regularly used to communicate the argument about the achievement of acceptable levels of safety for safety critical systems. Increasingly, safety standards such as Defence Standard 00-56 require the scope of the safety case to cover not only the development of the system, but also operating and maintenance through life, including decommissioning. This involves two dimension...

In previous papers, we asserted that software system safety is primarily concerned with epistemic questions, that is, questions concerning knowledge and the degree of confidence that can be placed in that knowledge. We also enumerated a set of 21 foundational epistemic questions, discussed some of the difficulties that exist in answering these questions adequately today, and speculated briefly ...