schemic preconditioning is the one maneuver that has onsistently been shown to reduce myocardial necrosis due o ischemia/reperfusion injury in experimental models (1). rief coronary occlusions of a few minutes to 10 min ollowed by brief reperfusion periods markedly reduce the ize of a subsequent myocardial infarction (MI) induced by longer coronary artery occlusion followed by reperfusion. he a...

d a v p s a o Background. The importance of moderate ischemic itral regurgitation in patients presenting for coronary rtery bypass grafting (CABG) is controversial. Thereore, we tracked the course of unrepaired moderate schemic mitral regurgitation after CABG surgery alone, dentified factors associated with worsening postoperaive ischemic mitral regurgitation, and assessed the imact of unrepair...

The present study investigated whether protein kinase C (PKC) plays a role in ischemic preconditioning in the rat heart. Chelerythrine, a specific antagonist of PKC, and 1,2-dioctanoyl-sn-glycerol (DOG), a diacylglycerol analogue and specific antagonist of PKC, were used to determine whether preconditioning could be blocked or triggered, respectively. Sprague-Dawley rats were anesthetized and i...

OBJECTIVE To analyze left ventricle performance after myocardial revascularization associated to ventricular geometrics restoration by "pacopexy" in schemic myocardiopathy patients with significant ventricular dysfunction in whom ventricular restoration was obtained through special technique. METHODS Myocardial revascularization associated to ventricular geometrics restoration through special...

Background: Remote ischemic preconditioning (RIPC) protects other organs from subsequent lethal ischemic injury, but uncertainty remains. We investigated if RIPC could prevent acute kidney injury (AKI) in patients undergoing coronary artery bypass graft (CABG) surgery.Methods: This parallel-group, double-blind, randomized, controlled trial was done on adults undergoing elective or urgent on-pum...

s m a p q c c want to share some information on the problem of schemic heart disease in women. Because of a focus on en, this topic has received inadequate attention, and the eneral assumption has been that what is true for men is also rue for women. In this overview, I will try to separate the acts from the wishful thinking that has evolved on this opic, largely due to deficiencies in our know...

We propose a suitable substitute for the classical Grothendieck ring of an algebraically closed field, in which any quasi-projective scheme is represented with its non-reduced structure. This yields a more subtle invariant, called the schemic Grothendieck ring. In order to include open subschemes and their complements, we introduce formal motives. Although originally cast in terms of definabili...

We propose a suitable substitute for the classical Grothendieck ring of an algebraically closed field, in which any quasi-projective scheme is represented, while maintaining its non-reduced structure. This yields a more subtle invariant, called the schemic Grothendieck ring, in which we can formulate a form of integration resembling Kontsevich’s motivic integration via arc schemes. In view of i...

Background—Ischemic heart disease is the greatest cause of death in Western countries. The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning (IPC), in which transient ischemia protects against subsequent severe ischemia/reperfusion injury. IPC activates multiple signaling pathways, including the reperfusion injury salvage kinase pathway (mainly PI3K-Akt-glycoge...