Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal ...

Univariate calibration method is a simple, cheap and easy to use procedure in analytical chemistry. A univariate analysis will be successful if a selective signal can be found for the analyte(s). In this work, two simple ways were used to find the selective signals, spectral ratio plot (SRP) and loading plot (LP). Both of them were able to discover the selective regions in the recorded data set...

Objective(s): Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on inflammatory pain. The contribution of opiate receptors was explored using non-selective and selective antagonists. Materials and Methods: The fourth ventricle of the brain of anesthetized rats was impla...

objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...

Background & aim: The decision on whether or not to do episiotomy is ultimately made by midwives. Problem-solving is an essential skill in the workplace situations, which help overcoming unpredictable circumstances without relying on the others. The aim of this study was to investigate the effect of problem-solving skills training on the frequency of selective episioto...

estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these kind of effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered as regulators of cns cytokines levels and neuroinflammation after tbi. m...

The ever increase of nonlinear loads in electric distribution networks causes many problems due to the high level of harmonic currents. This paper proposes a new technique for controlling a single phase shunt active power filter based on a selective compensation using the newly developed technique of harmonic control arrays. Simulation results confirm the appropriate selective harmonic compensa...

Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal ...