A polymethacrylate-based capillary monolithic column with zwitterionic functional groups was prepared by an in situ copolymerization method. The column was used in pressurized capillary electrochromatography (pCEC) for the separation of a test mixture of basic, neutral and acidic analytes. Unique manipulation of selectivity in pCEC was demonstrated by fine-tuning the applied voltage. The separa...

Fe is an impurity in most leach liquors. Its coexistence with copper in leaching solution of chalcopyrite (CuFeS2) which is the most important mineral of copper creates major extraction problems. Hydrochloric acid dissolves both copper and iron during chloride leaching of this mineral. Separation of Fe from Cu is thus necessary to obtain pure copper. This paper presents a novel metho...

In the pharmaceutical industry, the analysis of atropisomers is of considerable interest from a scientific and regulatory perspective. The compound of interest contains two stereogenic axes due to the hindered rotation around the single bonds connecting the aryl groups, which results in four potential configurational isomers (atropisomers). The separation of the four atropisomers is achieved on...

The aim of this study was to increase understanding of the mechanism and dominant drivers influencing phase separation during ram extrusion of calcium phosphate (CaP) paste for orthopaedic applications. The liquid content of extrudate was determined, and the flow of liquid and powder phases within the syringe barrel during extrusion were observed, subject to various extrusion parameters. Increa...

introduction: the mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. the effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. to further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14c] clozapine with suitable ra...