نتایج جستجو برای: sesamin

تعداد نتایج: 284  

2016
Pengyu Kong Guanghua Chen Anlong Jiang Yufu Wang Chengchao Song Jinpeng Zhuang Chunyang Xi Guangxi Wang Ye Ji Jinglong Yan

Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1β....

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2012
Kaori Yasuda Shinichi Ikushiro Shuto Wakayama Toshimasa Itoh Keiko Yamamoto Masaki Kamakura Eiji Munetsuna Miho Ohta Toshiyuki Sakaki

Sesamin and episesamin are two epimeric lignans that are found in refined sesame oil. Commercially available sesamin supplements contain both sesamin and episesamin at an approximate 1:1 ratio. Our previous study clarified the sequential metabolism of sesamin by cytochrome P450 (P450) and UDP-glucuronosyltransferase in human liver. In addition, we revealed that sesamin caused a mechanism-based ...

2014
Takashi Ide

We studied the combined effect of sesamin (1:1 mixture of sesamin and episesamine) and soybean phospholipid on lipid metabolism in rats. Male rats were fed diets supplemented with 0 or 2 g/kg sesamin, and containing 0 or 50 g/kg soybean phospholipid, for 19 days. Sesamin and soybean phospholipid decreased serum triacylglycerol concentrations and the combination of these compounds further decrea...

Journal: :The British journal of nutrition 2007
Jin Seon Lim Yoshikazu Adachi Yoko Takahashi Takashi Ide

Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats. Rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg) for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involve...

2017
Rumi UMEDA-SAwADA Yoko FuJIwARA

Sesamin is a lignan in sesame seed oil, and there are some reports on its various biological functions. Sesamin participates in the biological antioxidatiye reaction,i'2) an anticancer activity,2) and it has been recently reported that sesamin had ability to reduce liver damage caused by alcohol.3) Particularly, numerous studies abeut the infiuence of sesamin on lipid metabolism have been condu...

2012
Orawan Wanachewin Kanchanit Boonmaleerat Peraphan Pothacharoen Vichai Reutrakul Prachya Kongtawelert

BACKGROUND Osteoporosis is a worldwide health problem predominantly affecting post-menopausal women. Therapies aimed at increasing bone mass in osteoporetic patients lag behind comparable investigation of therapeutic strategies focusing on the bone resorption process. Sesamin, a major lignan compound found in Sesamun indicum Linn., has a variety of pharmacological effects, though its activity o...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Kaori Yasuda Shinichi Ikushiro Masaki Kamakura Eiji Munetsuna Miho Ohta Toshiyuki Sakaki

Our previous study revealed that CYP2C9 played a central role in sesamin monocatecholization. In this study, we focused on the metabolism of sesamin monocatechol that was further converted into the dicatechol form by cytochrome P450 (P450) or the glucuronide by UDP-glucuronosyltransferase (UGT). Catecholization of sesamin monocatechol enhances its antioxidant activity, whereas glucuronidation s...

2017
Warunee Srisuthtayanont Dumnoensun Pruksakorn Prachya Kongtawelert Peraphan Pothacharoen

BACKGROUND Numerous studies have reported on the health benefits of sesamin, a major lignin found in sesame (S. indicum) seeds. Recently, sesamin was shown to have the ability to promote chondroitin sulfate proteoglycan synthesis in normal human chondrocytes. This study assesses the anti-inflammatory effect of sesamin on proteoglycans production in 3D chondrocyte cultures. METHODS To evaluate...

Journal: :International journal of clinical and experimental pathology 2015
Dan Lv Chang-Qing Zhu Li Liu

Sesamin is naturally occurring lignan from sesame oil with putative antioxidant property. The present study was designed to investigate the protective role of sesamin against carbon tetrachloride induced oxidative liver injury. Male Wistar albino rats (180-200 g) were divided in to 5 groups (n=6). Hepatotoxicity was induced by the administration of CCl4 (0.1 ml/100 g bw., 50% v/v with olive oil...

2015
Kaori Yasuda Sera Ueno Erika Ueda Miyu Nishikawa Kie Takeda Masaki Kamakura Shinichi Ikushiro Toshiyuki Sakaki

Our previous studies revealed that sesamin caused a mechanism-based inhibition (MBI) of CYP2C9 in human liver microsomes. Additionally, we observed a similar MBI of CYP2C by sesamin in the rat liver microsomes. Sesamin-induced difference spectra of rat or human liver microsomes in the presence of NADPH showed a peak at 459 nm, suggesting the formation of a metabolic-intermediate (MI) complex of...

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