Flavonoids obtained from Sideritis species (Lamiaceae), S. raeseri and S. scardica, grown in Macedonia were studied. Qualitative and quantitative analyses of the flavonoid aglycones were performed using high-performance liquid chromatography (HPLC) with a UV diode array detector. Extracts were prepared by acid hydrolysis in acetone, re-extraction in ethyl acetate and evaporation to dryness; the...

Nowadays, Alzheimer's disease is the most prevalent epiphenomenon of the aging population. Although soluble amyloid-β (Aβ) species (monomers, oligomers) are recognized triggers of the disease, no therapeutic approach is able to stop it. Herbal medicines are used to treat different diseases in many regions of the world. On the Balkan Peninsula, at the eastern Mediterranean Sea, and adjacent regi...

Glutathione reductase (GR, E.C 1.6.4.2) is a flavoprotein that catalyzes NADPH-dependent reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH). The aim of this study was to investigate in vitro effects of phenolic compounds isolated from Sideritis brevibracteata on bovine kidney GR. The Sideritis species are widely found in nature and commonly used as medicinal plants. 7-O-glyco...

Gülaçtı TOPÇU*, Ahmet C. GÖREN *University of İstanbul, Faculty of Pharmacy, 34452, Beyazıt, İstanbul-TURKEY TÜBİTAK, Marmara Research Center, Department of Chemistry, P.O. Box 21, 41470, Gebze, Kocaeli-TURKEY Turgut KILIÇ, Y. Kemal YILDIZ Balıkesir University, Necatibey Education Faculty, Department of Chemistry, 10100 Balıkesir-TURKEY Gülendam TÜMEN Balıkesir University, Art and Science Facul...

Sideritis species have been known as medicinal plants since ancient times, and used as tea in Mediterranean countries such as Turkey, Greece and Spain. They are also used for the treatment of several ailments such as a cough, common cold and gastrointestinal disorders. The aim of the present study was to perform the chemical composition, antioxidant, anticholinesterase and anti-tyrosinase activ...

Sideritis species have been known as medicinal plants since ancient times, and used as tea in Mediterranean countries such as Turkey, Greece and Spain. They are also used for the treatment of several ailments such as a cough, common cold and gastrointestinal disorders. The aim of the present study was to perform the chemical composition, antioxidant, anticholinesterase and anti-tyrosinase activ...

Medicinal and aromatic plants are well appreciated for their antioxidant biocidal activities, while great variation on these activities can be related to the species, environmental conditions harvesting period. In present study, seasonal of activity, mineral content, yield chemical composition essential oils (EOs) sage (Salvia officinalis L.), sideritis (Sideritis perfoliata L. subsp. perfoliat...

The superoxide anion scavenging activity of 38 flavonoids, some of them isolated from Sideritis mugronensis, Sideritis javalambrensis and Cayaponia tayuya were investigated by measurement of their inhibition of nitroblue tetrazolium reduction. Isoorientin, orientin, amentoflavone, leucocyanidol, eriodictyol, datiscetin and robinetin behaved as potent scavengers and structure-activity relationsh...

Psychophysiological effects of Sideritis herba extracts depend on biologically active ingredients, which might be different for several botanical types of this plant. The present investigation aimed at the characterization of extracts from Sideritis scardica and Sideritis euboa in vivo and in vitro. Construction of electropharmacograms on the base of recording of electrical field potentials fro...

In this study, antibacterial, antifungal, antimycobacterial, cytotoxic, antitumor, cardiovascular, antifeedant, insecticidal, antileishmanial and some other single activities of diterpenoids and norditerpenoids isolated from Turkish Lamiaceae plants, are reviewed. The diterpenoids were isolated from species of Salvia, Sideritis, and Ballota species growing in Anatolia. Fifty abietanes, ten kaur...