Many fascinating new developments in the area bowed stringed instruments have been developed in recent years. However, the majority of these new applications are either not well known, used or considered in a broader context by their target users. The necessary exchange between the world of developers and the players is rather limited. A group of performers, researchers, instrument developers a...

One theory concerning the action of antidepressants relates to the drugs' ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to sigma-1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hyp...

sig Key {} sig Special, Regular extends Key {} one sig Control, Shift, Option, Command extends Special {} sig KeyPress {keys: set Key, event: Event} {one keys & Regular} sig Event {} fact {setObject (KeyPress, keys)} Note the use of Singleton to model the special keys. A prison database system tracks pairs of inmates who must not be placed in the same cell (because they belong to opposing gangs...

sig Target {} sig Addr extends Target {} abstract sig Name extends Target {} sig Alias, Group extends Name {} sig Book {addr: Name -> Target} Fig. 2.8 shows a model diagram, a graphical representation of the model’s declarations, generated automatically by the analyzer from the text above. Note that the addr field of Book now maps names to targets. A fig. 2.8 Model diagram for hierarchical addr...

The expression of Bcl-2, the major antiapoptotic member of the Bcl-2 family, is under complex controls of several factors, including reactive oxygen species (ROS). The sigma-1 receptor (Sig-1R), which was recently identified as a novel molecular chaperone at the mitochondria-associated endoplasmic reticulum membrane (MAM), has been shown to exert robust cellular protective actions. However, mec...

Sigma-1 receptors (Sig-1Rs) that bind diverse synthetic and endogenous compounds have been implicated in the pathophysiology of several human diseases such as drug addiction, depression, neurodegenerative disorders, pain-related disorders, and cancer. Sig-1Rs were identified recently as novel ligand-operated molecular chaperones. Although Sig-1Rs are predominantly expressed at endoplasmic retic...

A distributed video coding (DVC) system based on wavelet transform and set partition coding (SPC) is presented in this paper. Conventionally the significance map (sig-map) of SPC is not conducive to Slepian-Wolf (SW) coding, because of the difficulty of generating a side information sig-map and the sensitivity to decoding errors. The proposed DVC system utilizes a higher structured significance...

Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca(2+) signaling. In this review, we discuss the current understanding of S...

Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an alternative target for psychotherapeutic drugs. On the cellular level, when Sig-1R is activated, it is ...