Rapamycin, also known as sirolimus, inhibits the mTOR pathway in complex diseases such cancer, and its downstream targets are ribosomal S6 kinases (RPS6K). Sirolimus is involved regulating cell growth survival through roles mediation of epidermal factor signaling. However, systemic efficacy sirolimus regulation unclear. The purpose this study to determine drug using computational methods drug-i...

Abstract Purpose of Review The current review aims to explore recent studies that have illustrated a link between neuroinflammation and tinnitus the consequential effect on neuronal functioning. We parallels amongst pain pathologies novel treatment option. Recent Findings Genetic pharmacological blockage pro-inflammatory cytokines mitigates physiological behavioral phenotype in acute rodent mod...

Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...

in this review, we aim to examine the effect of extrinsic and intrinsic factors on spermatogenesis process taking into account a complex signaling pathway. primarily, it is suggested that retinoic acid (ra) has a vital function in spermatogenesis process and it is considered to be essential for completion of spermatogonia into mature spermatozoa. in the present review, the key effects of retino...