Nowadays herbal-derived medicines are attracting attention as new sources of drugs with few side effects. Silibinin is a flavonoid compound with chemotheraputic effects on different cancers such as examples in the prostate, lung, colon and breast. In the present study, the cytotoxic effects of silibinin on MCF7 breast cancer cells were investigated. Apoptosis was determined by flow cytometry an...

Breast cancer comprises 10.4% of all cancer incidences among women, making it the most common type of non-skin cancer in women and the fifth most common cause of cancer death. Silibinin, also known as silybin, is the major active constituent of silymarin. Silibinin has also demonstrated anticancer effects against human prostate adenocarcinoma cells, estrogen-dependent and – independent human br...

BACKGROUND Silibinin exerts hepatoprotective, anti-inflammatory and anti-fibrotic effects. Several pre-clinical studies have shown anti-tumoral activity of silibinin in breast cancer cell lines. CASE REPORT We present the case of a heavily pre-treated breast cancer patient with extensive liver infiltration. The patient presented with progressive liver failure despite several chemotherapy trea...

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymar...

BACKGROUND The efficacy of first-generation protease inhibitor based triple-therapy against hepatitis C virus (HCV) infection is limited in HIV/HCV-coinfected patients with advanced liver fibrosis and non-response to previous peginterferon-ribavirin. These patients have a low chance of achieving a sustained virologic response (SVR) using first generation triple-therapy, with a success rate of o...

conclusions the di was found to induce liver damage by oxidative stress mechanisms. silibinin reduced the oxidative stress by inducing antioxidant mechanisms, thereby showing protective effect against di induced liver damage. further studies with silibinin should be performed regarding di toxicity. materials and methods thirty two wistar albino rats were divided into four groups, as follows: 1)...

Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evaluated quantitative expression of miR-21 and miR-155 as two oncomiRs and seve...

In earlier studies, we demonstrated the efficacy of indole-3-carbinol (I3C) against lung adenocarcinoma in A/J mice. However, these effects were accompanied by reductions in body weight gain. We therefore assessed if combinations of low doses of I3C with silibinin could inhibit lung tumorigenesis without causing undesirable side effects. In in vitro assays with A549 and H460 lung cancer cells, ...

DOI: 10.4328/JCAM.4977 Received: 13.03.2017 Accepted: 19.04.2017 Published Online: 23.04.2017 Corresponding Author: Faruk Küçükdurmaz, Üroloji Anabilim Dalı, Sütçü İmam Üniversitesi Tıp Fakültesi, Kahramanmaraş, Türkiye. GSM: +905335409307 E-Mail:[email protected] Öz Amaç: İskemik priapizm, progresif hipoksi, hiperkapni ve asidozla seyreden ve sonrasında gelişen korporal fibrozisin erektil di...