The protective effect of methanolic extract of milk thistle seeds and silymarin against cisplatin-induced renal toxicity in male rats after a single intraperitoneal injection of 3 mg kg cisplatin were studied. Over 5 days, cisplatin-treated rats showed tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg kg) or ext...

This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level ...

The present study aimed to examine the effectiveness of silymarin compared to hydrocortisone on clinical and hematological alterations and organ injury (liver and heart) in a low-dose canine lipopolysaccharide (LPS)-induced sepsis model. Fifteen clinically healthy dogs were randomly categorized into three equal groups: Two dogs in group A, LPS (0.10 μg kg-1, IV) was injected (control...

Alcohol consumption is a common cause of acute and chronic hepatic toxicity in patients. Discovery novel therapeutic agents from medicinal plants most recommended because the presence diverse phytochemicals. The aim study to evaluate effect methanolic extract bark Albizia odoratissima on ethanol-induced hepatotoxicity rats. following objectives A. was screened for phytochemical analysis, tests ...

Background and objectives: Silymarin is a unique flavonoid complex with documented hepatoprotective properties. Silybum marianum hairy root culture as a source for producing silymarin has been an important strategy for study the cell signaling pathway. In the present investigation Trichoderma strainsSilybum marianum hairy root cultures interactions have been studied. Methods: The effects of two...

Silymarin, derived from the milk thistle plant Silybum marianum and widely used for self-treatment of liver diseases, is composed of six major flavonolignans including silybin A and silybin B, which are the predominant flavonolignans quantified in human plasma. The single- and multiple-dose pharmacokinetics of silymarin flavonolignans were examined in patients with nonalcoholic fatty liver dise...

Objective To describe and analyze the clinical characteristics and outcome of amatoxin poisoning cases. Methods We performed a retrospective cohort study of amatoxin poisoning cases from Ramathibodi Poison Center Toxic Exposure Surveillance System, from May 2013 to August 2015. Results There were 30 consultations with a total of 55 poisoning cases. Most cases were male and from the north-ea...

BACKGROUND Beta thalassemia is an inherited hemoglobin disorder resulting in a severe, chronic anemia requiring life-long blood transfusion that induces iron overload. Silymarin is a flavonoid complex isolated from Silybin marianum with a strong antioxidant activity, inducing an hepatoprotective action, and probably, a protective effect on iron overload. The aim of this work was to determine th...

this study aimed to investigate the effect of different levels of silymarin against lead induced oxidative stress in broiler chickens. therefore, 240 broiler chickens of ross 308 allocated to 24 experimental units in a completely randomized design with factorial 2x3 arrangements and four replicates of 10 birds. the experimental diets containing silymarin at 3 levels (0, 100, 200 mg/kg) and 2 le...