extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells. most lesions occur in the head and neck, primarily in the upper aerodigestive tract. the nasal cavity and nasal septum are the most common sites of occurrence. in this report, three patients admitted in our clinic with history of nasal obstruction and/or epistaxis. patients were diagnosed w...

sinonasal undifferentiated carcinoma is an extremely rare malignancy of the paranasal sinuses and nasal cavity. it is of unknown etiology, and occurs more commonly in the elderly men, with a routinely shown aggressive behavior and poor prognosis for survival. radiographically, it looks like severe osteomyelitis. histopathologic study is essential to confirm diagnosis, and the undifferentiated h...

PURPOSE OF REVIEW Sinonasal undifferentiated carcinoma is a rare and extremely malignant tumor of the paranasal sinuses. Historically, treatment outcomes have been poor. This review presents recent data on the management of sinonasal undifferentiated carcinoma and examines treatment trends that may result in improved locoregional control and survival. RECENT FINDINGS Patients who receive aggr...

Sinonasal tumors often mimick inflammatory diseases. If misdiagnosed, results are life threatening. This article comprises of study done on 5 patients who presented with nasal mass. They underwent clinical examination, diagnostic endoscopy, radiology and histopathological examination (HPE). Thorough evaluation helps the surgeon diagnose rare cases thus preventing detrimental outcomes. Herein we...

Sinonasal tract malignancies are uncommon, representing no more than 5% of all head and neck neoplasms. However, in contrast to other head and neck sites, a significant proportion of sinonasal neoplasms tend to display a poorly/ undifferentiated significantly overlapping morphology and a highly aggressive clinical course, despite being of diverse histogenetic and molecular pathogenesis. The wid...

PURPOSE The purpose of this paper is to discuss the treatment and outcomes for patients with sinonasal undifferentiated carcinoma. METHODS Review of the pertinent literature. RESULTS Most series contain a limited number of patients treated with various combinations of surgery, radiotherapy (RT), and chemotherapy. Follow-up periods for disease-free patients are sometimes relatively short. Th...

Introduction Malignant sinonasal tumors comprise less than 1% of all neoplasms. A wide variety of tumors occurring primarily in this site can present with an undifferentiated or poorly differentiated morphology. Among them are esthesioneuroblastomas, sinonasal undifferentiated carcinomas, and neuroendocrine carcinomas. Objectives We will discuss diagnostic strategies, recent advances in immunoh...

BACKGROUND Sinonasal undifferentiated carcinoma (SNUC) is an uncommon neoplasm characterized by local extension and an aggressive course. Treatment often includes a combination of chemotherapy, radiation therapy, and surgery, although the optimal strategy remains unclear. Here, we present the first reported case of leptomeningeal carcinomatosis from SNUC. METHODS AND RESULTS A 28-year-old man...

We present our experience with sinonasal undifferentiated carcinoma at the University of Michigan over 13 years and review prior published data. We conducted a retrospective review of 19 patients who presented to a tertiary care academic center multidisciplinary skull base clinic with sinonasal undifferentiated carcinoma between 1995 and 2008. Overall survival was 22% at 5 years, and the estima...