Locally oriented tissue engineering scaffolds can provoke cellular orientation and direct cell spread and migration, offering an exciting potential way for the regeneration of the complex tissue. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffolds with locally oriented hydrophilic polyacrylamide (PAM) inside the macropores of the scaffolds were achieved through UV graft polymerization...

Building on its high spatial resolution, deep penetration depth and excellent image contrast, 3D photoacoustic microscopy (PAM) has grown tremendously since its first publication in 2005. Integrating optical excitation and acoustic detection, PAM has broken through both the optical diffusion and optical diffraction limits. PAM has 100% relative sensitivity to optical absorption (i.e., a given p...

A cryogenic packaged vertical-cavity-surface-emitting laser (VCSEL) with microwave input and coupled OM4 fiber for optical output was developed demonstrated operation from 295 to 2.9 K. Record K data links of 100 Gbps pulsed amplitude modulation 4-level have been an energy per bit ∼153.4 fJ/bit when TDECQ = 3.79 dB. The energy/bit is limited by the link path bandwidth resulted cable loss VCSEL ...

Bisphosphonates (BPs) such as pamidronate are used to treat bone destructive diseases and act by inhibiting bone resorption by osteoclasts, thereby improving bone quality. In contrast, BPs were shown to stimulate osteoclast formation and resorption at the mouse molar root. Periodontal ligament (PDL) fibroblasts could be seen as the mediators of osteoclast formation at this location. Here, we in...

Melphalan (L-PAM) has been an integral part of multiple myeloma (MM) treatment as a conditioning regimen before stem cell transplant (SCT). After initial response, most treated patients experience relapse with an aggressive phenotype. Increased glutathione (GSH) in MM may mediate resistance to L-PAM. We demonstrated that the GSH synthesis inhibitor buthionine sulfoximine (BSO) synergistically e...

Polyacrylamide (PAM) is a water-soluble polymer that is widely used as a flocculant in sewage treatment. The accumulation of PAM affects the formation of dewatered sludge and potentially produces hazardous monomers. In the present study, the bacterial strain HI47 was isolated from dewatered sludge. This strain could metabolize PAM as its sole nutrient source and was subsequently identified as P...

Metastasis and drug resistance are major barriers for the treatment of non-small cell lung cancer (NSCLC). To explore new therapeutic options, we successfully encapsulated MicroRNA-34a (miR-34a), a potent endogenous tumor suppressor in NSCLC into S6 aptamer-conjugated dendrimer to form lung cancer-targeted gene delivery nanoparticles (PAM-Ap/pMiR-34a NPs). PAM-Ap/pMiR-34a NPs had a diameter of ...

Analog photonic computing has been proposed and tested in recent years as an alternative approach for data recovery fiber transmission systems. Photonic reservoir computing, performing nonlinear transformations of the transmitted signals exhibiting internal fading memory, found advantageous this kind processing. In work, we show that effectiveness memory depends significantly on properties sign...