OBJECTIVE(S) There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced analgesia. In this study, we investigated the effect of permanent lesion of the RVM on SIA by using formalin test as a model of acute inflammatory pai...

Introduction: Dopamine plays an important role in the central nervous system for modulating food intake. Dopamine receptors are distributed within the hypothalamus, and expression of D1 receptors is significant in hypothalamic paraventricular nucleus (PVN). Therefore, the aim of this study was to find if PVN-microinjected SKF38393, D1 receptor agonist, may modulate food intake. Methods: Gui...

Maternal cues entrain a circadian pacemaker in fetal Syrian hamsters. These cues may act through dopaminergic activation of the fetal suprachiasmatic nucleus (SCN); injection of the dopamine D1 agonist SKF38393 to pregnant hamsters entrains activity rhythms of their pups and induces expression of c-fos in the fetal SCN. The aim of this study was to examine the ability of SKF38393 to entrain neo...

objective(s): there are many reports about the role of rostral ventromedial medulla (rvm) in modulating stress-induced analgesia (sia). in the previous study we demonstrated that temporal inactivation of rvm by lidocaine potentiated stress-induced analgesia. in this study, we investigated the effect of permanent lesion of the rvm on sia by using formalin test as a model of acute inflammatory pa...

introduction: dopamine plays an important role in the central nervous system for modulating food intake. dopamine receptors are distributed within the hypothalamus, and expression of d1 receptors is significant in hypothalamic paraventricular nucleus (pvn). therefore, the aim of this study was to find if pvn-microinjected skf38393, d1 receptor agonist, may modulate food intake. methods: guide c...

The interactions between N-methyl-D-aspartate (NMDA) and D(1) dopamine receptors in the rat prefrontal cortex were examined using whole-cell recordings from pyramidal neurons. The effects of NMDA, the D(1) agonist SKF38393, or both compounds combined were tested on measures of cell excitability. Both NMDA (10-100 microM) and SKF38393 (5-10 microM) independently increased the number of spikes an...

In the present study, the effects of intra-locus coeruleus injection of a dopamine D(1) receptor agonist (SKF38393) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an index of withdrawal intensity for comparison. The D(1) agonist and antagonist were injected 15 a...

In animal models of Parkinson's disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute striatal slices from rodents with unilateral 6-hydroxydopamine (6-OHDA) lesions. Application of the d...

Objective(s): There are many reports about the role of rostral ventromedial medulla (RVM) in modulating stress-induced analgesia (SIA). In the previous study we demonstrated that temporal inactivation of RVM by lidocaine potentiated stress-induced analgesia. In this study, we investigated the effect of permanent lesion of the RVM on SIA by using formalin test as a model of acute inflammatory pa...

Background. This study's goal was to provide dose-response data for a dopamine agonist in the baboon using standard methods (replicate measurements at each dose, across a range of doses), as a standard against which to subsequently validate a novel pharmacological MRI (phMRI) method. Dependent variables were functional MRI (fMRI) data from brain regions selected a priori, and systemic prolactin...