نتایج جستجو برای: skov3

تعداد نتایج: 770  

Journal: :Oncology reports 2007
Xue-Dong Yan Min Li Ye Yuan Ning Mao Ling-Ya Pan

Drug resistance is one of the major obstacles to chemotherapy of ovarian cancer. Studies with cell lines can serve as an initial screen for agents that might modulate drug resistance. To establish more appropriate models of drug resistance and explore whether the differences exist in the different drug resistant sublines selected by different treatments, we induced SKOV3 cell line using cisplat...

2013
Ting Shuang Chunxue Shi Shuang Chang Min Wang Cui Hong Bai

To better understand the molecular mechanisms of paclitaxel resistance in ovarian carcinoma, we evaluated the expression of miRNAs using miRNA microarray between human ovarian carcinoma SKOV3 cells and paclitaxel resistant SKOV3-TR30 cells. Results showed that 69 miRNAs were upregulated while 102 miRNAs were downregulated in SKOV3-TR30 cells. Using real-time PCR, we further clarified that miR...

Journal: :Genetics and molecular research : GMR 2015
Y J Tang Z L Sun W G Wu J Xing Y F He D M Xin P Han

The aim of the present study was to investigate the anti-ovarian cancer effect of the inhibitor of signal transducer and activator of transcription 3 (STAT3), WP1066. Western blot was used to detect the phosphorylation of STAT3 in ovarian cancer cell line SKOV3 and cisplatin-resistant ovarian cancer cell line SKOV3/DDP. MTT and colony-forming assays were performed to evaluate the viability and ...

2014
Wei Wu Li-hua Yu Bei Ma Ming-juan Xu

BACKGROUND Detecting a new effective and hypotoxic anticancer drug is an emerging new strategy for cancer chemotherapy. Doxycycline (DC) is a kind of antibiotics but also inhibits tumorigenesis. METHODS MTT and cell invasion assay, flow cytometry, western-blot analysis and nude mice were used to investigate the effects and underlying mechanisms of doxycycline on epithelial ovarian cancer cell...

Journal: :Oncology reports 2015
Ye Xu Chunyan Wang Jing Su Qi Xie Liwei Ma Linchuan Zeng Yang Yu Shibing Liu Songyan Li Zhixin Li Liankun Sun

The mechanism of cisplatin resistance in ovarian cancer is not fully understood. In the present study, we showed a critical role for endoplasmic reticulum (ER) stress tolerance in mediating cisplatin resistance in human ovarian cancer cells. We found cisplatin to inhibit the proliferation of two ovarian cancer cell lines: cisplatin-sensitive SKOV3 cells and cisplatin‑resistant SKOV3/DDP cells. ...

Journal: :Oncology reports 2013
Ning Liu Ye Xu Ji-Tong Sun Jing Su Xi-Yan Xiang Hao-Wei Yi Zhi-Chao Zhang Lian-Kun Sun

SKOV3/DDP human ovarian cancer cells have been shown to be resistant to cisplatin. Although the BH3 mimetic S1 induces cell death in several types of tumor cells, it is unclear whether it induces death in drug-resistant cells. Herein, we found that S1 induced endoplasmic reticulum (ER) stress-associated apoptosis in both SKOV3 and SKOV3/DDP cells. S1 activated autophagy at early time points in ...

Journal: :Oncology reports 2012
Lingyun Yang Ningwei Li Hongjing Wang Xibiao Jia Xue Wang Juan Luo

microRNAs (miRNAs) are short non-coding RNA molecules which are involved in the regulation of various biological processes. Drug resistance has become a major obstacle to successful chemotherapy of ovarian cancer. The aim of this study was to investigate microRNA expression profiles in cisplatin-resistant ovarian cancer cells and the role of miR-1...

Journal: :International journal of clinical and experimental medicine 2015
Zhengmao Zhang Zhen Xie Guangyu Sun Pingfang Yang Jia Li Hongfang Yang Shuang Xiao Yang Liu Hongbing Qiu Lijun Qin Chao Zhang Fenghua Zhang Baoen Shan

OBJECTIVE To investigate the mechanisms for reversing drug resistance of cisplatin (DDP) by Hsp90 inhibitors (geldanamycin (GA), 17-AAG, 17-DMAG) in human ovarian cancer. METHODS Cell proliferation rate in DDP resistant human ovarian cancer cell line SKOV3/DDP and its parent cell line SKOV3 after treatment with Hsp90 inhibitors and/or DDP were tested by MTT assay, and the reversing fold (RF) ...

2015
Tang Yiwei Huang Hua Guo Hui Meng Mao Long Xiang

BACKGROUND The aim of this study was to evaluate the effect of when silencing HOTAIR in ovarian cancer skov3 cells on proliferation, migration, and invasion, and to elucidate the mechanism by which this occurs. MATERIAL AND METHODS We detected the mRNA level of HOTAIR (HOX antisense intergenic RNA) and MAPK1 (mitogen-activated protein kinase 1) in ovarian cancer SKOV3, ES-2, OVCAR3, A2780, an...

2017
Yanyu Li Ling Liu Zeyuan Yin Hui Xu Shuang Li Wei Tao Hui Cheng Lei Du Xueyuan Zhou Bei Zhang

The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and p-nuclear factor (NF)-κB protein was detected by western blot analysis. The w...

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