cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (nsclc). many novel drugs have been used in combination with cisplatin in this setting. of these drugs, gemcitabine is reported to have a high response rate and acceptable toxicity. the aim of this study was to evaluate the efficacy and safety of gemcitabine and cisplatin combination. twentythree pati...

biomolecular behavior of tumor cells has become attractive to investigators. p53 as an oncosuppresor gene has been core of various studies and ki67 is a nuclear protein involved in proliferation process. stopping of onco-suppressor function theoretically allows proliferative system to get out of any control. in this case-control study we evaluated 50 patients with non small cell lung cancer, co...

introduction: primary small cell carcinoma of theesophagus (pscec) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. the lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. s...

intussusception is common cause of bowel obstruction in the paediatric age group compared to the elderly population. many times, the diagnosis may be difficult because of asymptomatic nature of this bowel disorder. we hereby describe the case of a 75-year-old male who presented with lethargy, weakness, loss of movement in the joints and was found to be anemic. the haemoglobin level was low so h...

aims: the backbone of treatment in advanced non-small cell lung cancer is platinum-based doublet chemotherapy. we intended to compare the effectiveness of two commonly used regimens in real world practice. methods: this single institute, parallel comparative post marketing study included 100 patients with chemo-naïve advanced (stage iiib, iv) non-small cell lung cancer and eastern cooperative o...

background: cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (nsclc). many novel drugs, including gemcitabine, vinorelbine, paclitaxel and docetaxel have been used in combination with cisplatin in this setting. of these drugs, gemcitabine is reported to have a high response rate and acceptable toxicity. the aim of this study was to evaluate the effi...

intra-abdominal desmoplastic small round cell tumor is a rare entity with a few reports worldwide. this tumor commonly occurs in children and adolescent and occurrence in adult age group is very rare. here, we describe an adult male with symptoms of intestinal obstruction due to abdominal mass, located in splenic flexure. after resection, the diagnosis of intra-abdominal desmoplastic small roun...

conclusion the technical performance of pet scan is significantly higher than similar technologies for staging and treatment of nsclc. in addition, it might slightly improve the treatment process and lead to a small level of increase in the quality adjusted life year (qaly) gained by these patients making it cost-effective for the treatment of nsclc. results the total annual running cost of a p...

conclusions primary scec is a rare and highly aggressive tumor. however, prognosis is poor and long-term survival is exceptional. crt could be an appropriate alternative to operation. patients and methods this brief report was carried out by reviewing the medical records of 22 patients with newly histologically proven scec that were treated between 2000 and 2010 at 2 tertiary academic hospitals...

desmoplastic small round cell tumor (dscrt) is a rare variant of sarcoma with a highly aggressive behavior. it usually affects abdominal cavity and has a male predominance. its correct diagnosis and treatment is sophisticated and requires an experienced multidisciplinary team. hereby we present a 25 yrold man from kerman province in 2013 with abdominal mass and ascites who underwent sonograghy ...