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objective: pmbn, poly [2-methacryloyloxyethyl phosphoryl choline (mpc)-co-n- buthyl methacrylate (bma)-co-p-nitrophenyl- oxycrabonyl poly (ethylene glycol-methacrylate (meonp)], as a biocompatible ter-polymer is a unique polymer with wide range of application from drug delivery systems to scaffolds and biomedical devices. in this research, monomer of p- nitrophenyl- oxycarbonyl poly (ethylene g...

We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are co...

nowadays, environment-sensitive smart drug delivery systems have found diverse applications in pharmaceutical science and technology. these systems can respond to the environment stimuli such as temperature, pressure, ph, light, electrical and magnetical fields and etc. they can release the proper amount of drug in human body. among these systems, special attention and much research works have ...

Smart polymers have enormous potential in various applications. In particular, smart polymeric drug delivery systems have been explored as "intelligent" delivery systems able to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration i...

Debabrata Payra, Masanobu Naito, * Yoshihisa Fujii, and Yuki Nagao a Research Center for Strategic Materials, Structural Materials Unit, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan b Advanced Key Technologies Division, Polymer Materials Unit, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan c School ...

A novel self-sensing framework, utilizing embedded cyclobutane-based mechanophores, was developed for identifying damage precursors and propagation. The novel "smart" material was incorporated into a thermoset polymer matrix and the color change phenomenon was observed under compressive loading. The smart material based polymer system was used to construct glass fiver reinforced composites to i...

Here we demonstrate the effectiveness of an electroresponsive aqueous silk protein polymer as a smart mechanical damping fluid. The aqueous polymer solution is liquid under ambient conditions, but is reversibly converted into a gel once subjected to an electric current, thereby increasing or decreasing in viscosity. This nontoxic, biodegradable, reversible, edible fluid also bonds to device sur...

Temperature- and electric field-responsive polymer-conjugated polystyrene beads, termed smart beads, are designed to isolate cancer cells. In smart beads, the reversible "on-off" antigen-antibody reaction and dielectrophoresis force on an electrode are accomplished to realize "on-off" remote manipulation of smart beads and cancer cells. Both the zeta-potential and the hydrodynamic diameter of t...

Electrostatic self-assembly was used to fabricate new smart multi-layer coatings, using a recombinant elastin-like polymer (ELP) and chitosan as the counterion macromolecule. The ELP was bioproduced, purified and its purity and expected molecular weight were assessed. Aggregate size measurements, obtained by light scattering of dissolved ELP, were performed as a function of temperature and pH t...