ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. the present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by kci and acetylcholine, compared with the effects of other drugs. ketotifen (5 µm) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shifted t...

introduction: we did this study because there were a few studies about aorto-branch junction. methods: four light microscope and electron microscope study, the abdominal aorta, renal artery, and the adjoining right and left renal arteries were dissected out from 4 neonate dogs. results: based on the results, there is only one cell type in the tunica intima of endothelium in both arteries. in ab...

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administ...

saffron, crocus sativus l. (c. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. these therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. the effect of c. sativus and its constituents on different smooth muscles an...

Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concent...

Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concent...

bunium persicum (boiss.) is an economically important medicinal plant growing wild in arid regions in iran. the essential oil of b. persicum (eobp) was extracted using hydrodistillation. a total of eighteen compounds, representing 96.14 % of the oil was identified by gas chromatography/mass spectrometry (gc/ms).the main compounds were cuminaldehyde (23.04 %), gamma-terpinene (14.48 %), trans-3-...

background and objectives: uterine smooth muscle tumors are the most common human neoplasm .they are divided clinically as benign and malignant but there is  another group of  lesions which is difficult to place in these two categories ,so-called smooth  muscle tumors of uncertain malignant potential (stump) and differentiation  of these tumors on the basis of h&e staining is impossible . t...

osteonectin is a bone- associated protein involved in vascular calcification. adiponectin may protect against cardiovascular disease but possible effects on vascular calcification have been poorly studied. the aim of this study was to investigate the modulatory effect of adiponectin on oxidized low density lipoprotein (oxldl)- induced expression of osteonectin in human aorta vascular smooth mus...