نتایج جستجو برای: soluble cd163

تعداد نتایج: 90385  

Journal: :iranian journal of allergy, asthma and immunology 0
mehrdad farrokhi department of neurology, school of medicine, isfahan university of medical sciences, isfahan, iran zahra saadatpour department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran elyas fadaee faculty of  medicine, islamic azad university of najafabad, najafabad, iran leila saadatpour department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran ali rezaei department of radiology, school of medicine, najafabad university of medical sciences, najafabad, iran pedram moeini department of neurology, school of medicine, isfahan university of medical sciences, isfahan, iran

multiple sclerosis (ms) is an autoimmune disease of central nervous system. since different types of immune cells are involved in ms pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble cd4 (scd4), scd8, scd163, and immunoglobulins as markers of activity of t-cells, macrophages, and b-cells in different types of ms. serum levels of ...

2017
Anders Etzerodt Ronan M. G. Berg Ronni R. Plovsing Morten N. Andersen Magali Bebien Mohamed Habbeddine Toby Lawrence Holger J. Møller Søren K. Moestrup

CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma 'soluble CD163' (sCD163) has become a biomarker for macrophage activity and inflammation. The present study disclosed that 10% of sCD163 in healthy persons is ac...

2015
Hirokuni Akahori Vinit Karmali Rohini Polavarapu Alicia N. Lyle Daiana Weiss Eric Shin Ahsan Husain Nawazish Naqvi Richard Van Dam Anwer Habib Cheol Ung Choi Adrienne L. King Kimberly Pachura W. Robert Taylor David J. Lefer Aloke V. Finn

Macrophages are an essential component of the immune response to ischaemic injury and play an important role in promoting inflammation and its resolution, which is necessary for tissue repair. The type I transmembrane glycoprotein CD163 is exclusively expressed on macrophages, where it acts as a receptor for haemoglobin:haptoglobin complexes. An extracellular portion of CD163 circulates in the ...

Journal: :Circulation research 2007
Andrew P Levy K Raman Purushothaman Nina S Levy Meerarani Purushothaman Merav Strauss Rabea Asleh Stuart Marsh Osher Cohen Soren K Moestrup Holger J Moller Elias A Zias Daniel Benhayon Valentin Fuster Pedro R Moreno

In individuals with diabetes mellitus (DM), the haptoglobin (Hp) genotype is a major determinant of susceptibility to myocardial infarction. We have proposed that this is because of DM and Hp genotype-dependent differences in the response to intraplaque hemorrhage. The macrophage hemoglobin scavenging receptor CD163 plays an essential role in the clearance of hemoglobin released from lysed red ...

Journal: :Journal of leukocyte biology 2002
Katharine A Hintz Athos J Rassias Kathleen Wardwell Marcia L Moss Peter M Morganelli Patricia A Pioli Alice L Givan Paul K Wallace Mark P Yeager Paul M Guyre

CD163, a monocyte and macrophage-specific surface glycoprotein, which is increased by interleukin-10 and glucocorticoids, is a scavenger receptor for hemoglobin/haptoglobin complexes. We report a rapid and highly reproducible rise in soluble CD163 in the plasma of human volunteers given intravenous lipopolysaccharide (LPS). We also show that LPS induces shedding of CD163 from the surface of iso...

2011
Emma Tippett Wan-Jung Cheng Clare Westhorpe Paul U. Cameron Bruce J. Brew Sharon R. Lewin Anthony Jaworowski Suzanne M. Crowe

CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1 infection on monocyte and macrophage biology. CD163 co-expression on CD14+CD16++ monocytes has been p...

2011
Rajeev B. Ahuja

monocytes and macrophages by proand antiinflammatory stimuli. J Leukoc Biol 2000;67:97-103. 4. Moestrup SK, Moller HJ. CD163. A regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004;36:347-54. 5. Droste A, Sorg C, Hogger P. Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteinerich family. Biochem Biophys Res...

Journal: :Folia histochemica et cytobiologica 2011
Krzysztof Kowal Richard Silver Emila Sławińska Marek Bielecki Lech Chyczewski Otylia Kowal-Bielecka

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleu...

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