نتایج جستجو برای: soluble cd8

تعداد نتایج: 127547  

Journal: :iranian journal of allergy, asthma and immunology 0
mehrdad farrokhi department of neurology, school of medicine, isfahan university of medical sciences, isfahan, iran zahra saadatpour department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran elyas fadaee faculty of  medicine, islamic azad university of najafabad, najafabad, iran leila saadatpour department of radiology, school of medicine, isfahan university of medical sciences, isfahan, iran ali rezaei department of radiology, school of medicine, najafabad university of medical sciences, najafabad, iran pedram moeini department of neurology, school of medicine, isfahan university of medical sciences, isfahan, iran

multiple sclerosis (ms) is an autoimmune disease of central nervous system. since different types of immune cells are involved in ms pathogenesis, in this study we aimed to evaluate serum levels of several immunological components including soluble cd4 (scd4), scd8, scd163, and immunoglobulins as markers of activity of t-cells, macrophages, and b-cells in different types of ms. serum levels of ...

Journal: :European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993
D Fuchs M Samsonov G P Tilz G Reibnegger J N Belenkov E L Nassonov H Wachter

In this cross-sectional study, we analysed serum concentrations of soluble markers of cellular immune activation, namely, interferon-gamma, neopterin (a product of activated macrophages), soluble interleukin-2 receptor, and soluble CD8, in 25 patients with congestive heart failure. Ten (40%) patients showed increased concentrations (i.e. above the reference ranges of healthy controls) of neopte...

Journal: :Journal of immunology 2006
Jennifer D Stone Lawrence J Stern

T cell activation is initiated by recognition of antigenic peptide presented in complex with MHC molecules on the surface of APCs. The mechanism by which this recognition occurs is still unclear, and many models exist in the literature. CD4 T cells have been shown to respond to soluble oligomers of activating class II MHC-peptide complexes, but not to soluble monomers. In determining the reacti...

2005
Yeonseok Chung Jae-Hoon Chang Mi-Na Kweon Paul D. Rennert Chang-Yuil Kang

Cross-presentation is a critical process by which antigen is displayed to CD8 T cells to induce tolerance. It is believed that CD8 dendritic cells (DCs) are responsible for cross-presentation, suggesting that the CD8 DC population is capable of inducing both cross-priming and cross-tolerance to antigen. We found that cross-tolerance against intestinal soluble antigen was abrogated in C57BL/6 mi...

Journal: :Journal of immunology 2000
L Lefrançois J D Altman K Williams S Olson

The signals directing induction of tolerance rather than immunity are largely unknown. The CD8 T cell response to soluble Ags generally results in deletional tolerance following transient, costimulation-dependent activation. We demonstrated that CD40 signaling reversed the outcome of this response. Adoptive transfer of OVA-specific CD8 T cells followed by soluble OVA immunization resulted in in...

2007
David K. Cole Pierre J. Rizkallah Jonathan M. Boulter Malkit Sami Anne-lise Vuidepot Meir Glick Feng Gao John I. Bell Bent K. Jakobsen George F. Gao

Human CD8 is a T cell coreceptor, which binds to pHLA I and plays a pivotal role in the activation of cytotoxic T lymphocytes. Soluble recombinant CD8 aa has been shown to antagonize T cell activation, both in vitro and in vivo. However, because of a very low affinity for pHLA I, high concentrations of soluble CD8 aa are required for efficient inhibition. Based upon our knowledge of the wild-ty...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Tomohiro Osaki Hiroaki Saito Toshiaki Yoshikawa Sachiko Matsumoto Shigeru Tatebe Shunichi Tsujitani Masahide Ikeguchi

PURPOSE Some studies suggest that the immunoreceptor NKG2D expression on CD8(+) T cells is down-regulated and this reduction may be involved in immune evasion in cancer patients. The present study was designed to investigate NKG2D expression on CD8(+) T lymphocytes and its relationship to immune evasion in gastric cancer patients. EXPERIMENTAL DESIGN NKG2D expression on both circulating and t...

Journal: :Clinical & Experimental Immunology 2008

Journal: :International immunology 2000
F Puppo P Contini M Ghio S Brenci M Scudeletti G Filaci S Ferrone F Indiveri

In the present study, we have evaluated the apoptotic effect of soluble human MHC class I (sHLA-I) antigens on CD8(+) T lymphocytes. sHLA-I antigens and beta(2)-microglobulin-free HLA class I heavy chains, isolated from serum, induced apoptosis on phytohemagglutinin-activated CD8(+) T lymphocytes in autologous and allogeneic combinations. The extent of CD8(+) T cell apoptosis depends on the deg...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Eckart Schott Nicolas Bertho Qing Ge Madelon M Maurice Hidde L Ploegh

Crosslinking of the T cell receptor has been proposed to be a prerequisite for T cell activation. Although the evidence supports this notion for CD4 T cells, the situation for CD8 T cells is less clear. Soluble class I monomers have been used to determine activation requirements in vitro with contradictory results. The possibility of transfer of peptide from soluble class I molecules onto class...

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