the adhesion molecules are involved in adhesion of leukocytes to endothelial cells and other immune cells. not only adhesion molecules have membrane form, but they also have soluble form. in this paper, we attempted to investigate the concen¬tration of soluble adhesion molecules in the type 1 diabetic patients (n = 40) and healthy subjects (n = 10). the results indicated that there was an incre...

Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...

endothelial dysfunction is thought to be a central pathogenic feature in preeclampsia on the basis of elevated adhesion molecules. soluble forms of these molecules can be detected in plasma, and their concentrations are thought to reflect the degree of activation of a particular cell type. the aim of the present study was to compare the levels of soluble vascular cell adhesion molecule-1 (svcam...

Since their development approximately a decade ago, cell adhesion molecules have been attracting interest for a number of reasons. For example, the blockade of the interaction between leukocytes and the endothelium by agents that mimic or inhibit these adhesion molecules may provide the basis for a new class of therapeutic agents, although promising studies in animals1–3 have yet to be translat...

Sepsis is a severe and life-threatening systemic inflammatory response to infection that affects all populations and age groups. The pathophysiology of sepsis is associated with aberrant interaction between leukocytes and the vascular endothelium. As inflammation progresses, the adhesion molecules that mediate these interactions become shed from cell surfaces and accumulate in the blood as solu...

Several membrane-bound molecules expressed at the surface of tumor cells have been shown to be released in a soluble form, thereby affecting cell-cell interactions by reduction of ligand densities. Moreover, since the binding domain of the soluble molecules often remains functional, proteolytic cleavage can also reduce the recognition of tumor cells by effector cells bearing the corresponding r...

platelet activation and adhesion to the site of vascular injury is a dynamic process comprising reversible and irreversible phases. platelet adhesion typically occurs in a multi-step process similar to the selectin/integrin-mediated adhesion of neutrophils. this phenomenon is highly regulated and influenced by the cross-talk between platelets and injured endothelium. this cross-talk involves a ...