stats are a family of latent transcription factors that reside in the cytoplasm of resting cells. the stat1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cm. this factor upon stimulation with inf gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. in this study, we estimated the allele and genotype frequencies of stat1/pag1 gen...

STATs are a family of latent transcription factors that reside in the cytoplasm of resting cells. The STAT1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cM. This factor upon stimulation with INF gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. In this study, we estimated the allele and genotype frequencies of STAT1/Pag<...

STATs are a family of latent transcription factors that reside in the cytoplasm of resting cells. The STAT1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cM. This factor upon stimulation with INF gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. In this study, we estimated the allele and genotype frequencies of STAT1/Pag<...

this study was conducted to investigate the single nucleotide polymorphism of stat1 gene by pcr-rflp technique and association of genotypes with milk production traits in brown swiss dairy cattle. the blood samples of ninety eight cows were collected randomly from tail vein. the dna was extracted with cinagene kit (pr881612c). fragment of 314 bp of stat1 gene was amplified by pcr and digested b...

Abstract In this study, we performed RNA sequencing of Prx II +/+ and ?/? dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role in DMSCs, Gene Ontology analysis DEGs. The results showed that DEGs were mainly involved biological processes cell migration, intercellular adhesion, coordination regulation homing. Through construction protein–pro...

Signal transducer and activator of transcription (STAT) proteins are both tyrosine- and serine-phosphorylated, mediating signal transduction and gene regulation. Following gene regulation, STAT activity in the nucleus is then terminated by a nuclear protein phosphatase(s), which remains unidentified. Using novel antibody arrays to screen the Stat1-specific protein phosphatase(s), we identified ...

Neurons are chiefly nonrenewable; thus, cytolytic immune strategies to clear or control neurotropic viral infections could have lasting neurologic consequences. IFN-γ is a potent antiviral cytokine that is critical for noncytolytic clearance of multiple neurotropic viral infections, including measles virus (MV); however, the downstream pathways through which IFN-γ functions in neurons have not ...

Interferon (IFN) treatment induces tyrosine phosphorylation and nuclear translocation of Stat1 (signal transducer and activator of transcription) to activate or repress transcription. We report here that a member of the protein inhibitor of activated STAT family, PIASy, is a transcriptional corepressor of Stat1. IFN treatment triggers the in vivo interaction of Stat1 with PIASy, which represses...

BACKGROUND The signal transducer and activator of transcription (STAT) family of transcription factors mediates a variety of cytokine dependent gene regulations. STAT1 has been mainly characterized by its role in interferon (IFN) type I and II signaling and STAT1 deficiency leads to high susceptibility to several pathogens. For fine-tuned analysis of STAT1 function we established a dimerizer-in...

STATs are activated by tyrosine phosphorylation on cytokine stimulation. A tyrosine-phosphorylated STAT forms a functional dimer through reciprocal Src homology 2 domain (SH2)-phosphotyrosyl peptide interactions. IFN treatment induces the association of PIAS1 and Stat1, which results in the inhibition of Stat1-mediated gene activation. The molecular basis of the cytokine-dependent PIAS1-Stat1 i...